Histone deacetylase-10 liberates spermidine to support polyamine homeostasis and tumor cell growth

Cytosolic histone deacetylase-10 (HDAC10) specifically deacetylates the modified polyamine N(8)-acetylspermidine (N(8)-AcSpd). Although intracellular concentrations of N(8)-AcSpd are low, extracellular sources can be abundant, particularly in the colonic lumen. Extracellular polyamines, including th...

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Detalles Bibliográficos
Autores principales: Stewart, Tracy Murray, Foley, Jackson R., Holbert, Cassandra E., Klinke, Glynis, Poschet, Gernot, Steimbach, Raphael R., Miller, Aubry K., Casero, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486564/
https://www.ncbi.nlm.nih.gov/pubmed/35988653
http://dx.doi.org/10.1016/j.jbc.2022.102407

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