Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA

Legionella pneumophila, a bacterial pathogen that causes a severe pneumonia known as Legionnaires’ disease, extensively exploits the ubiquitin (Ub) pathway in the infected host cells through certain virulence effectors excreted by the Dot/Icm system. To date, several Dot/Icm effectors have been foun...

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Detalles Bibliográficos
Autores principales: Luo, Jiwei, Ruan, Xinglin, Huang, Zhijie, Li, Zekai, Ye, Le, Wu, Yongyu, Zhen, Xiangkai, Ouyang, Songying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486567/
https://www.ncbi.nlm.nih.gov/pubmed/36007613
http://dx.doi.org/10.1016/j.jbc.2022.102414

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