Cargando…

DrDimont: explainable drug response prediction from differential analysis of multi-omics networks

MOTIVATION: While it has been well established that drugs affect and help patients differently, personalized drug response predictions remain challenging. Solutions based on single omics measurements have been proposed, and networks provide means to incorporate molecular interactions into reasoning....

Descripción completa

Detalles Bibliográficos
Autores principales:	Hiort, Pauline, Hugo, Julian, Zeinert, Justus, Müller, Nataniel, Kashyap, Spoorthi, Rajapakse, Jagath C, Azuaje, Francisco, Renard, Bernhard Y, Baum, Katharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Systems Track
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486584/ https://www.ncbi.nlm.nih.gov/pubmed/36124784 http://dx.doi.org/10.1093/bioinformatics/btac477

Ejemplares similares

Analysis of correlation-based biomolecular networks from different omics data by fitting stochastic block models
por: Baum, Katharina, et al.
Publicado: (2019)

Design centering enables robustness screening of pattern formation models
por: Solomatina, Anastasia, et al.
Publicado: (2022)

A deep neural network approach to predicting clinical outcomes of neuroblastoma patients
por: Tranchevent, Léon-Charles, et al.
Publicado: (2019)

Explaining Chaos
por: Smith, Peter
Publicado: (1998)

The LHCb Track Extrapolator Tools
por: Bos, E, et al.
Publicado: (2007)

Deep learning and multi-omics approach to predict drug responses in cancer
por: Wang, Conghao, et al.
Publicado: (2022)

Combining Neuroimaging and Omics Datasets for Disease Classification Using Graph Neural Networks
por: Chan, Yi Hao, et al.
Publicado: (2022)

Network-based integration of multi-omics data for clinical outcome prediction in neuroblastoma
por: Wang, Conghao, et al.
Publicado: (2022)

Achieving model explainability for intrusion detection in VANETs with LIME
por: Hassan, Fayaz, et al.
Publicado: (2023)

Computational Model of Chimeric Antigen Receptors Explains Site-Specific Phosphorylation Kinetics
por: Rohrs, Jennifer A., et al.
Publicado: (2018)

Bioinformatics and biomarker discovery: "Omic" data analysis for personalized medicine
por: Azuaje, Francisco
Publicado: (2010)

A Framework for Learning Event Sequences and Explaining Detected Anomalies in a Smart Home Environment
por: Baudisch, Justin, et al.
Publicado: (2022)

The MultiOmics Explainer: explaining omics results in the context of a pathway/genome database
por: Paley, Suzanne, et al.
Publicado: (2019)

A Force Balance Can Explain Local and Global Cell Movements during Early Zebrafish Development
por: Chai, Jack, et al.
Publicado: (2015)

Quantitative metabolic fluxes regulated by trans-omic networks
por: Ohno, Satoshi, et al.
Publicado: (2022)

Antibody neutralization capacity after coronavirus disease 2019 vaccination in people with HIV in Canada
por: Costiniuk, Cecilia T., et al.
Publicado: (2023)

Dr. Gaston Explains
por: Gaston, J. McF.
Publicado: (1887)

Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach
por: Tranchevent, Léon-Charles, et al.
Publicado: (2018)

Georges Charpak invents the multi-wire proportional chamber, which was to revolutionise the field of particle detection (1992 Nobel Prize in physics)
por: CERN PhotoLab
Publicado: (1973)

The 50 m long BCDMS apparatus, with particle detectors sandwiched between slabs of magnetized iron, tracked the paths of muons after they scattered off atoms' nuclei.
Publicado: (2004)

Russian and Belorussian firms receive CMS Gold Awards
Publicado: (2003)

Light guide for NA49 experiment
Publicado: (1997)

DELPHI: Hadron detection
Publicado: (1992)

L3: Decay of Z0 to three jets
Publicado: (1991)

L3: Decay of Z0 to muon-antimuon pair
Publicado: (1991)

ALEPH: Decay of Z0 to two jets
Publicado: (1991)

L3: Decay of Z0 to positron-electron pair
Publicado: (1991)

Inside view of the target system
Publicado: (1994)

DIRAC detector experiment: general view of the downstream part of the set-up
por: Patrice Loïez
Publicado: (1999)

DIRAC detector experiment: the drift chambers (seen from the side) and photo tubes of one set of horizontal hodoscopes
por: Patrice Loïez
Publicado: (1999)

DIRAC detector experiment: preshowers (on the left) and Cherenkov counters (on the right)
por: Patrice Loïez
Publicado: (1999)

DIRAC detector experiment: one set of muon counters
por: Patrice Loïez
Publicado: (1999)

DIRAC detector experiment: muon counters (on the left), cast iron filter and preshowers (on the right)
por: Patrice Loïez
Publicado: (1999)

DIRAC detector experiment: support for the micro strip gas chambers (on the left), the 2 modules of the fibre detector on the first plane of the ionization detector (on the right)
por: Patrice Loïez
Publicado: (1999)

DIRAC detector experiment: the vacuum chamber (blue), beginning of the flat chamber (yellow), magnetic screen (orange) in front of the magnet. The vacuum tube for the primary proton beam is below (sil ver color)
por: Patrice Loïez
Publicado: (1999)

DIRAC detector experiment: the primary proton beam line, the target station (rectangular box) and the beginning of the vacuum box (blue) which will contains primary and secondary beams
por: Patrice Loïez
Publicado: (1999)

DIRAC detector experiment: general view of the concrete radiation shielding surrounding the set-up
por: Laurent Guiraud
Publicado: (1999)

Photogrammetry of a CMS endcap and part of the hadronic calorimeter. The structure was covered by targets photographed by the numerical cameras
Publicado: (2003)

ALICE: Simulated lead-lead collision
Publicado: (2003)

The "g-2" Muon Storage Ring
por: CERN PhotoLab
Publicado: (1974)

Cannot write session to /tmp/vufind_sessions/sess_d0bmprrpojh00b3iui6jh2jt3h