The value of BCL2 and CK20 expression in predicting behavioral patterns of bladder cancer, a cross sectional study

BACKGROUND: Several biomarkers have been investigated to predict the biological behavior and prognosis of patients with bladder cancer. We evaluated the role of two important markers including BCL2 and CK20 in evaluating the biological behavior of bladder tumors. METHODS: This cross-sectional study was performed on 30 patients suffering from one of the neoplasms of the bladder. To evaluate the expression of BCL2 and CK20 markers, the neoplastic tissue sample was initially extracted and immunohistochemistry staining was employed. RESULTS: The positivity of CK20 and BCL2 in the patients’ specimens was found to be 53.3% and 10.0%, respectively. There was no association between CK20 and BCL2 expressions and tumor size, tumor stage, or tumor-related vascular invasion, but BCL2 expression was shown to be higher in the low-grade specimens, while the expression rate of CK20 was found to be significantly higher in high grade samples. CONCLUSION: Evaluation of the expression of CK20 and BCL2 markers can be very valuable in predicting bladder tumor grade.