Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis

[Image: see text] The hydrogen bonding network that surrounds the flavin in blue light using flavin adenine dinucleotide (BLUF) photoreceptors plays a crucial role in sensing and communicating the changes in the electronic structure of the flavin to the protein matrix upon light absorption. Using ti...

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Detalles Bibliográficos
Autores principales: Tolentino Collado, Jinnette, Iuliano, James N., Pirisi, Katalin, Jewlikar, Samruddhi, Adamczyk, Katrin, Greetham, Gregory M., Towrie, Michael, Tame, Jeremy R. H., Meech, Stephen R., Tonge, Peter J., Lukacs, Andras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486806/
https://www.ncbi.nlm.nih.gov/pubmed/36038143
http://dx.doi.org/10.1021/acschembio.2c00575

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