Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments

[Image: see text] Development of small molecules targeting the PD-L1/PD-1 interface is advancing both in industry and academia, but only a few have reached early-stage clinical trials. Here, we take a closer look at the general druggability of PD-L1 using in silico hot spot mapping and nuclear magne...

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Detalles Bibliográficos
Autores principales: Kitel, Radoslaw, Rodríguez, Ismael, del Corte, Xabier, Atmaj, Jack, Żarnik, Magdalena, Surmiak, Ewa, Muszak, Damian, Magiera-Mularz, Katarzyna, Popowicz, Grzegorz M., Holak, Tad A., Musielak, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486809/
https://www.ncbi.nlm.nih.gov/pubmed/36073782
http://dx.doi.org/10.1021/acschembio.2c00583

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