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Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement

[Image: see text] Determining a molecule’s mechanism of action is paramount during chemical probe development and drug discovery. The cellular thermal shift assay (CETSA) is a valuable tool to confirm target engagement in cells for a small molecule that demonstrates a pharmacological effect. CETSA d...

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Detalles Bibliográficos
Autores principales:	Sanchez, Tino W., Ronzetti, Michael H., Owens, Ashley E., Antony, Maria, Voss, Ty, Wallgren, Eric, Talley, Daniel, Balakrishnan, Krishna, Leyes Porello, Sebastian E., Rai, Ganesha, Marugan, Juan J., Michael, Samuel G., Baljinnyam, Bolormaa, Southall, Noel, Simeonov, Anton, Henderson, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486815/ https://www.ncbi.nlm.nih.gov/pubmed/36049119 http://dx.doi.org/10.1021/acschembio.2c00334

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