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Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S(N)i Mechanism and Ion Pair Transition State

[Image: see text] Toxins TcdA and TcdB from Clostridioides difficile glucosylate human colon Rho GTPases. TcdA and TcdB glucosylation of RhoGTPases results in cytoskeletal changes, causing cell rounding and loss of intestinal integrity. Clostridial toxins TcdA and TcdB are proposed to catalyze gluco...

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Detalles Bibliográficos
Autores principales:	Paparella, Ashleigh S., Cahill, Sean M., Aboulache, Briana L., Schramm, Vern L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486934/ https://www.ncbi.nlm.nih.gov/pubmed/36038138 http://dx.doi.org/10.1021/acschembio.2c00408

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