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Biosynthesis of the Unusual Carbon Skeleton of Nocuolin A

[Image: see text] Nocuolin A is a cytotoxic cyanobacterial metabolite that is proposed to be produced by enzymes of the noc biosynthetic gene cluster. Nocuolin A features a 1,2,3-oxadiazine moiety, a structural feature unique among natural products and, so far, inaccessible through organic synthesis...

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Detalles Bibliográficos
Autores principales: Martins, Teresa P., Glasser, Nathaniel R., Kountz, Duncan J., Oliveira, Paulo, Balskus, Emily P., Leão, Pedro N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486936/
https://www.ncbi.nlm.nih.gov/pubmed/36044983
http://dx.doi.org/10.1021/acschembio.2c00464

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