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Biosynthesis of the Unusual Carbon Skeleton of Nocuolin A
[Image: see text] Nocuolin A is a cytotoxic cyanobacterial metabolite that is proposed to be produced by enzymes of the noc biosynthetic gene cluster. Nocuolin A features a 1,2,3-oxadiazine moiety, a structural feature unique among natural products and, so far, inaccessible through organic synthesis...
Autores principales: | Martins, Teresa P., Glasser, Nathaniel R., Kountz, Duncan J., Oliveira, Paulo, Balskus, Emily P., Leão, Pedro N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486936/ https://www.ncbi.nlm.nih.gov/pubmed/36044983 http://dx.doi.org/10.1021/acschembio.2c00464 |
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