Structurally Informed Mutagenesis of a Stereochemically Promiscuous Aldolase Produces Mutants That Catalyze the Diastereoselective Syntheses of All Four Stereoisomers of 3-Deoxy-hexulosonic Acid

[Image: see text] A 2-keto-3-deoxygluconate aldolase from the hyperthermophile Sulfolobus solfataricus catalyzes the nonstereoselective aldol reaction of pyruvate and d-glyceraldehyde to produce 2-keto-3-deoxygluconate (d-KDGlc) and 2-keto-3-deoxy-d-galactonate (d-KDGal). Previous investigations int...

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Detalles Bibliográficos
Autores principales: Royer, Sylvain F., Gao, Xuan, Groleau, Robin R., van der Kamp, Marc W., Bull, Steven D., Danson, Michael J., Crennell, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486944/
https://www.ncbi.nlm.nih.gov/pubmed/36158901
http://dx.doi.org/10.1021/acscatal.2c03285

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