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Association of advanced paternal age with lung function at school age
BACKGROUND: Epidemiological studies suggest that advanced paternal age impact offspring health, but its impact on respiratory health is unclear. This study aimed to investigate the association of paternal age with lung function and fraction of exhaled nitric oxide (FeNO) in children. METHODS: We ana...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487029/ https://www.ncbi.nlm.nih.gov/pubmed/36127724 http://dx.doi.org/10.1186/s12931-022-02178-4 |
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author | Gau, Chun-Chun Lee, Hsin-Ju Lu, Hung-Yi Wu, Chao-Yi Huang, Hsin-Yi Tsai, Hui-Ju Yao, Tsung-Chieh |
author_facet | Gau, Chun-Chun Lee, Hsin-Ju Lu, Hung-Yi Wu, Chao-Yi Huang, Hsin-Yi Tsai, Hui-Ju Yao, Tsung-Chieh |
author_sort | Gau, Chun-Chun |
collection | PubMed |
description | BACKGROUND: Epidemiological studies suggest that advanced paternal age impact offspring health, but its impact on respiratory health is unclear. This study aimed to investigate the association of paternal age with lung function and fraction of exhaled nitric oxide (FeNO) in children. METHODS: We analyzed data from 1330 single-born children (576 girls, 43.3%; mean age, 6.4 years), who participated in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort and received measurements of lung function and FeNO at 6-year follow-up visits. Covariate-adjusted regression analyses were applied. RESULTS: Every 5-year increase in paternal age at birth was associated with 0.51% decrease in FEV(1)/FVC ratio (95% CI − 0.86 to − 0.15; p = 0.005) and 19.86 mL/s decrease in FEF(75) (95% CI: − 34.07 to − 5.65; p = 0.006). Stratified analyses revealed that increasing paternal age at birth was associated with decreasing FEV(1)/FVC ratio and FEF(75) only among children with prenatal exposure to environmental tobacco smoke (ETS) or not being breastfed. Sensitivity analyses using paternal age as a categorical variable found decreasing FEV(1)/FVC ratio and FEF(75) in the groups of paternal age 35–39 and ≥ 40 years. There was no association of paternal age at birth with FeNO. CONCLUSION: Our findings provide novel evidence linking advanced paternal age at birth with decreasing lung function in children at school age. Children with prenatal exposure to ETS or not being breastfed are more vulnerable to the adverse effect of advanced paternal age on childhood lung function. Further studies are warranted to confirm this novel adverse effect of advanced paternal age. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12931-022-02178-4. |
format | Online Article Text |
id | pubmed-9487029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94870292022-09-21 Association of advanced paternal age with lung function at school age Gau, Chun-Chun Lee, Hsin-Ju Lu, Hung-Yi Wu, Chao-Yi Huang, Hsin-Yi Tsai, Hui-Ju Yao, Tsung-Chieh Respir Res Research BACKGROUND: Epidemiological studies suggest that advanced paternal age impact offspring health, but its impact on respiratory health is unclear. This study aimed to investigate the association of paternal age with lung function and fraction of exhaled nitric oxide (FeNO) in children. METHODS: We analyzed data from 1330 single-born children (576 girls, 43.3%; mean age, 6.4 years), who participated in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort and received measurements of lung function and FeNO at 6-year follow-up visits. Covariate-adjusted regression analyses were applied. RESULTS: Every 5-year increase in paternal age at birth was associated with 0.51% decrease in FEV(1)/FVC ratio (95% CI − 0.86 to − 0.15; p = 0.005) and 19.86 mL/s decrease in FEF(75) (95% CI: − 34.07 to − 5.65; p = 0.006). Stratified analyses revealed that increasing paternal age at birth was associated with decreasing FEV(1)/FVC ratio and FEF(75) only among children with prenatal exposure to environmental tobacco smoke (ETS) or not being breastfed. Sensitivity analyses using paternal age as a categorical variable found decreasing FEV(1)/FVC ratio and FEF(75) in the groups of paternal age 35–39 and ≥ 40 years. There was no association of paternal age at birth with FeNO. CONCLUSION: Our findings provide novel evidence linking advanced paternal age at birth with decreasing lung function in children at school age. Children with prenatal exposure to ETS or not being breastfed are more vulnerable to the adverse effect of advanced paternal age on childhood lung function. Further studies are warranted to confirm this novel adverse effect of advanced paternal age. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12931-022-02178-4. BioMed Central 2022-09-20 2022 /pmc/articles/PMC9487029/ /pubmed/36127724 http://dx.doi.org/10.1186/s12931-022-02178-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Gau, Chun-Chun Lee, Hsin-Ju Lu, Hung-Yi Wu, Chao-Yi Huang, Hsin-Yi Tsai, Hui-Ju Yao, Tsung-Chieh Association of advanced paternal age with lung function at school age |
title | Association of advanced paternal age with lung function at school age |
title_full | Association of advanced paternal age with lung function at school age |
title_fullStr | Association of advanced paternal age with lung function at school age |
title_full_unstemmed | Association of advanced paternal age with lung function at school age |
title_short | Association of advanced paternal age with lung function at school age |
title_sort | association of advanced paternal age with lung function at school age |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487029/ https://www.ncbi.nlm.nih.gov/pubmed/36127724 http://dx.doi.org/10.1186/s12931-022-02178-4 |
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