The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: a multiparametric quantitative and spatial analysis unveils a rationale to target treatment-naïve tumors with immune checkpoint inhibitors

BACKGROUND: Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squamous cell carcinoma in the first- and second-line settings. However, only 15–20% of patients benefit from this treatment, a feature increasingly ascribed to the peculi...

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Detalles Bibliográficos
Autores principales: Tosi, Anna, Parisatto, Beatrice, Menegaldo, Anna, Spinato, Giacomo, Guido, Maria, Del Mistro, Annarosa, Bussani, Rossana, Zanconati, Fabrizio, Tofanelli, Margherita, Tirelli, Giancarlo, Boscolo-Rizzo, Paolo, Rosato, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487049/
https://www.ncbi.nlm.nih.gov/pubmed/36123711
http://dx.doi.org/10.1186/s13046-022-02481-4

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