The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise

BACKGROUND: Exercise and some pre-AKI diets have been shown to improve injury, apoptosis, and lipid profile. In this study, the effect of two different diets along with exercise training on acute kidney injury (AKI) was investigated.  MATERIALS AND METHODS: Laboratory rats were randomly divided into...

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Autores principales: Sabet, Nazanin, Soltani, Zahra, Khaksari, Mohammad, Iranpour, Maryam, Afshar, Reza Malekpour, Mehdiabadi, Fatemeh Mousavi, Raji-Amirhasani, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487158/
https://www.ncbi.nlm.nih.gov/pubmed/36123655
http://dx.doi.org/10.1186/s12882-022-02938-w
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author Sabet, Nazanin
Soltani, Zahra
Khaksari, Mohammad
Iranpour, Maryam
Afshar, Reza Malekpour
Mehdiabadi, Fatemeh Mousavi
Raji-Amirhasani, Alireza
author_facet Sabet, Nazanin
Soltani, Zahra
Khaksari, Mohammad
Iranpour, Maryam
Afshar, Reza Malekpour
Mehdiabadi, Fatemeh Mousavi
Raji-Amirhasani, Alireza
author_sort Sabet, Nazanin
collection PubMed
description BACKGROUND: Exercise and some pre-AKI diets have been shown to improve injury, apoptosis, and lipid profile. In this study, the effect of two different diets along with exercise training on acute kidney injury (AKI) was investigated.  MATERIALS AND METHODS: Laboratory rats were randomly divided into four groups of control, standard diet + exercise, exercise + calorie restriction (CR) and exercise + time restriction (TR). Each group was divided into two subgroups of AKI and no AKI. The animals received endurance training and diet regimens before AKI. Fasting blood glucose, serum creatinine, Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl2) and histopathological outcome of renal tissue as well as serum lipid profile of animals were assessed 24 h after AKI.  RESULTS: The percentage of changes in renal Bcl2 and Bax after AKI in the group with previous exercise was lower than the group without previous exercise (p < 0.01). After induction of AKI, serum lipid profile changed in non-exercised rats (p < 0.001). Also, after injury, fasting blood glucose levels increased in non-exercised rats (p < 0.05). After injury, the start of both CR and TR diets during exercise caused less change in Bcl2 and Bax of non-exercised rats compared to exercised rats (p < 0.001). CR diet along with exercise improved lipid profile, and also CR diet along exercise decreased fasting blood glucose levels (p < 0.001). Also, both the CR and TR diets during exercise caused fewer changes in histopathological outcome after AKI. CONCLUSION: Exercise alone decreased changes in apoptotic and histopathological indexes, fasting blood glucose, as well as lipid profile of rats after AKI. Reduction of apoptosis and improvement of histopathological outcome after AKI appeared more when CR and TR diets were commenced during exercise. The reduction of lipid profile changes was more pronounced in the group that received CR diet during exercise.
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spelling pubmed-94871582022-09-21 The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise Sabet, Nazanin Soltani, Zahra Khaksari, Mohammad Iranpour, Maryam Afshar, Reza Malekpour Mehdiabadi, Fatemeh Mousavi Raji-Amirhasani, Alireza BMC Nephrol Research BACKGROUND: Exercise and some pre-AKI diets have been shown to improve injury, apoptosis, and lipid profile. In this study, the effect of two different diets along with exercise training on acute kidney injury (AKI) was investigated.  MATERIALS AND METHODS: Laboratory rats were randomly divided into four groups of control, standard diet + exercise, exercise + calorie restriction (CR) and exercise + time restriction (TR). Each group was divided into two subgroups of AKI and no AKI. The animals received endurance training and diet regimens before AKI. Fasting blood glucose, serum creatinine, Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl2) and histopathological outcome of renal tissue as well as serum lipid profile of animals were assessed 24 h after AKI.  RESULTS: The percentage of changes in renal Bcl2 and Bax after AKI in the group with previous exercise was lower than the group without previous exercise (p < 0.01). After induction of AKI, serum lipid profile changed in non-exercised rats (p < 0.001). Also, after injury, fasting blood glucose levels increased in non-exercised rats (p < 0.05). After injury, the start of both CR and TR diets during exercise caused less change in Bcl2 and Bax of non-exercised rats compared to exercised rats (p < 0.001). CR diet along with exercise improved lipid profile, and also CR diet along exercise decreased fasting blood glucose levels (p < 0.001). Also, both the CR and TR diets during exercise caused fewer changes in histopathological outcome after AKI. CONCLUSION: Exercise alone decreased changes in apoptotic and histopathological indexes, fasting blood glucose, as well as lipid profile of rats after AKI. Reduction of apoptosis and improvement of histopathological outcome after AKI appeared more when CR and TR diets were commenced during exercise. The reduction of lipid profile changes was more pronounced in the group that received CR diet during exercise. BioMed Central 2022-09-19 /pmc/articles/PMC9487158/ /pubmed/36123655 http://dx.doi.org/10.1186/s12882-022-02938-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Sabet, Nazanin
Soltani, Zahra
Khaksari, Mohammad
Iranpour, Maryam
Afshar, Reza Malekpour
Mehdiabadi, Fatemeh Mousavi
Raji-Amirhasani, Alireza
The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise
title The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise
title_full The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise
title_fullStr The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise
title_full_unstemmed The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise
title_short The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise
title_sort effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487158/
https://www.ncbi.nlm.nih.gov/pubmed/36123655
http://dx.doi.org/10.1186/s12882-022-02938-w
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