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Cough in idiopathic pulmonary fibrosis
Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is mos...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487209/ https://www.ncbi.nlm.nih.gov/pubmed/27581827 http://dx.doi.org/10.1183/16000617.0090-2015 |
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author | van Manen, Mirjam J.G. Birring, Surinder S. Vancheri, Carlo Cottin, Vincent Renzoni, Elisabetta A. Russell, Anne-Marie Wijsenbeek, Marlies S. |
author_facet | van Manen, Mirjam J.G. Birring, Surinder S. Vancheri, Carlo Cottin, Vincent Renzoni, Elisabetta A. Russell, Anne-Marie Wijsenbeek, Marlies S. |
author_sort | van Manen, Mirjam J.G. |
collection | PubMed |
description | Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably “multifactorial” and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF. |
format | Online Article Text |
id | pubmed-9487209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94872092022-11-14 Cough in idiopathic pulmonary fibrosis van Manen, Mirjam J.G. Birring, Surinder S. Vancheri, Carlo Cottin, Vincent Renzoni, Elisabetta A. Russell, Anne-Marie Wijsenbeek, Marlies S. Eur Respir Rev Reviews Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably “multifactorial” and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF. European Respiratory Society 2016-09 /pmc/articles/PMC9487209/ /pubmed/27581827 http://dx.doi.org/10.1183/16000617.0090-2015 Text en Copyright ©ERS 2016. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Reviews van Manen, Mirjam J.G. Birring, Surinder S. Vancheri, Carlo Cottin, Vincent Renzoni, Elisabetta A. Russell, Anne-Marie Wijsenbeek, Marlies S. Cough in idiopathic pulmonary fibrosis |
title | Cough in idiopathic pulmonary fibrosis |
title_full | Cough in idiopathic pulmonary fibrosis |
title_fullStr | Cough in idiopathic pulmonary fibrosis |
title_full_unstemmed | Cough in idiopathic pulmonary fibrosis |
title_short | Cough in idiopathic pulmonary fibrosis |
title_sort | cough in idiopathic pulmonary fibrosis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487209/ https://www.ncbi.nlm.nih.gov/pubmed/27581827 http://dx.doi.org/10.1183/16000617.0090-2015 |
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