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Cough in idiopathic pulmonary fibrosis

Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is mos...

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Detalles Bibliográficos
Autores principales: van Manen, Mirjam J.G., Birring, Surinder S., Vancheri, Carlo, Cottin, Vincent, Renzoni, Elisabetta A., Russell, Anne-Marie, Wijsenbeek, Marlies S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487209/
https://www.ncbi.nlm.nih.gov/pubmed/27581827
http://dx.doi.org/10.1183/16000617.0090-2015
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author van Manen, Mirjam J.G.
Birring, Surinder S.
Vancheri, Carlo
Cottin, Vincent
Renzoni, Elisabetta A.
Russell, Anne-Marie
Wijsenbeek, Marlies S.
author_facet van Manen, Mirjam J.G.
Birring, Surinder S.
Vancheri, Carlo
Cottin, Vincent
Renzoni, Elisabetta A.
Russell, Anne-Marie
Wijsenbeek, Marlies S.
author_sort van Manen, Mirjam J.G.
collection PubMed
description Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably “multifactorial” and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF.
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spelling pubmed-94872092022-11-14 Cough in idiopathic pulmonary fibrosis van Manen, Mirjam J.G. Birring, Surinder S. Vancheri, Carlo Cottin, Vincent Renzoni, Elisabetta A. Russell, Anne-Marie Wijsenbeek, Marlies S. Eur Respir Rev Reviews Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably “multifactorial” and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF. European Respiratory Society 2016-09 /pmc/articles/PMC9487209/ /pubmed/27581827 http://dx.doi.org/10.1183/16000617.0090-2015 Text en Copyright ©ERS 2016. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Reviews
van Manen, Mirjam J.G.
Birring, Surinder S.
Vancheri, Carlo
Cottin, Vincent
Renzoni, Elisabetta A.
Russell, Anne-Marie
Wijsenbeek, Marlies S.
Cough in idiopathic pulmonary fibrosis
title Cough in idiopathic pulmonary fibrosis
title_full Cough in idiopathic pulmonary fibrosis
title_fullStr Cough in idiopathic pulmonary fibrosis
title_full_unstemmed Cough in idiopathic pulmonary fibrosis
title_short Cough in idiopathic pulmonary fibrosis
title_sort cough in idiopathic pulmonary fibrosis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487209/
https://www.ncbi.nlm.nih.gov/pubmed/27581827
http://dx.doi.org/10.1183/16000617.0090-2015
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