Towards personalised therapy for lymphangioleiomyomatosis: lessons from cancer

Lymphangioleiomyomatosis (LAM) is a rare cystic, destructive lung disease occurring almost exclusively in females. Bi-allelic inactivating tuberous sclerosis complex (TSC) gene mutations occur in LAM cells, resulting in activation of the mTORC1 pathway. Pivotal clinical trials have demonstrated that...

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Detalles Bibliográficos
Autores principales: El-Chemaly, Souheil, Henske, Elizabeth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2014
Materias:
Mini Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487253/
https://www.ncbi.nlm.nih.gov/pubmed/24591659
http://dx.doi.org/10.1183/09059180.00008813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487253/
https://www.ncbi.nlm.nih.gov/pubmed/24591659
http://dx.doi.org/10.1183/09059180.00008813

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