Cargando…
Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies
Myocardial injury and necrosis caused by hyperlipidemia have been investigated by several researchers. Their pathogenesis and molecular basis are different from those of the more common clinical ischemic myocardial injury. Hyperlipidemia leads to peroxide accumulation in the cardiomyocytes, causes l...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487343/ https://www.ncbi.nlm.nih.gov/pubmed/36110037 http://dx.doi.org/10.12659/MSM.937051 |
_version_ | 1784792462365032448 |
---|---|
author | Zhang, Zhiqi Wu, Hongyi Wang, Tao Liu, Yao Meng, Chun |
author_facet | Zhang, Zhiqi Wu, Hongyi Wang, Tao Liu, Yao Meng, Chun |
author_sort | Zhang, Zhiqi |
collection | PubMed |
description | Myocardial injury and necrosis caused by hyperlipidemia have been investigated by several researchers. Their pathogenesis and molecular basis are different from those of the more common clinical ischemic myocardial injury. Hyperlipidemia leads to peroxide accumulation in the cardiomyocytes, causes lipid overload, decreases the antioxidant capacity of the body, and promotes the inflammatory response. Furthermore, hyperlipidemia causes changes in the structure and function of mitochondria in the cardiomyocytes, which results in their injury and necrosis. Many previous studies have shown that metabolic diseases (eg, obesity and diabetes) and chemical poisoning can lead to hyperlipidemic myocardial injury and necrosis. Moreover, it has been observed that this pathological process can be inhibited by many small molecular substances. In the clinic, myocardial damage can be prevented or reduced by lowering the levels of triglyceride and cholesterol. Myocardial damage can also be regulated via the molecular pathway of myocardial injury caused by hyperlipidemia so that the disease can be treated. The present article reviewed the recent findings reported on the mechanisms of myocardial damage due to hyperlipidemia. |
format | Online Article Text |
id | pubmed-9487343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94873432022-10-20 Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies Zhang, Zhiqi Wu, Hongyi Wang, Tao Liu, Yao Meng, Chun Med Sci Monit Review Articles Myocardial injury and necrosis caused by hyperlipidemia have been investigated by several researchers. Their pathogenesis and molecular basis are different from those of the more common clinical ischemic myocardial injury. Hyperlipidemia leads to peroxide accumulation in the cardiomyocytes, causes lipid overload, decreases the antioxidant capacity of the body, and promotes the inflammatory response. Furthermore, hyperlipidemia causes changes in the structure and function of mitochondria in the cardiomyocytes, which results in their injury and necrosis. Many previous studies have shown that metabolic diseases (eg, obesity and diabetes) and chemical poisoning can lead to hyperlipidemic myocardial injury and necrosis. Moreover, it has been observed that this pathological process can be inhibited by many small molecular substances. In the clinic, myocardial damage can be prevented or reduced by lowering the levels of triglyceride and cholesterol. Myocardial damage can also be regulated via the molecular pathway of myocardial injury caused by hyperlipidemia so that the disease can be treated. The present article reviewed the recent findings reported on the mechanisms of myocardial damage due to hyperlipidemia. International Scientific Literature, Inc. 2022-09-16 /pmc/articles/PMC9487343/ /pubmed/36110037 http://dx.doi.org/10.12659/MSM.937051 Text en © Med Sci Monit, 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Review Articles Zhang, Zhiqi Wu, Hongyi Wang, Tao Liu, Yao Meng, Chun Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies |
title | Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies |
title_full | Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies |
title_fullStr | Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies |
title_full_unstemmed | Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies |
title_short | Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies |
title_sort | mechanisms of myocardial damage due to hyperlipidemia: a review of recent studies |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487343/ https://www.ncbi.nlm.nih.gov/pubmed/36110037 http://dx.doi.org/10.12659/MSM.937051 |
work_keys_str_mv | AT zhangzhiqi mechanismsofmyocardialdamageduetohyperlipidemiaareviewofrecentstudies AT wuhongyi mechanismsofmyocardialdamageduetohyperlipidemiaareviewofrecentstudies AT wangtao mechanismsofmyocardialdamageduetohyperlipidemiaareviewofrecentstudies AT liuyao mechanismsofmyocardialdamageduetohyperlipidemiaareviewofrecentstudies AT mengchun mechanismsofmyocardialdamageduetohyperlipidemiaareviewofrecentstudies |