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Therapeutic strategies in pneumonia: going beyond antibiotics
Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therape...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487679/ https://www.ncbi.nlm.nih.gov/pubmed/26324814 http://dx.doi.org/10.1183/16000617.0034-2015 |
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author | Müller-Redetzky, Holger Lienau, Jasmin Suttorp, Norbert Witzenrath, Martin |
author_facet | Müller-Redetzky, Holger Lienau, Jasmin Suttorp, Norbert Witzenrath, Martin |
author_sort | Müller-Redetzky, Holger |
collection | PubMed |
description | Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therapeutic targets have been identified and numerous innovative therapeutic approaches demonstrated to improve lung injury in experimental preclinical studies. However, at present specific preventive or curative strategies for the treatment of lung failure in pneumonia in addition to antibiotics are still missing. The aim of this mini-review is to give a short overview of some, but not all, adjuvant therapeutic strategies for pneumonia and its most important complications, sepsis and acute respiratory distress syndrome, and briefly discuss future perspectives. |
format | Online Article Text |
id | pubmed-9487679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94876792022-11-14 Therapeutic strategies in pneumonia: going beyond antibiotics Müller-Redetzky, Holger Lienau, Jasmin Suttorp, Norbert Witzenrath, Martin Eur Respir Rev Lung Science Conference Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therapeutic targets have been identified and numerous innovative therapeutic approaches demonstrated to improve lung injury in experimental preclinical studies. However, at present specific preventive or curative strategies for the treatment of lung failure in pneumonia in addition to antibiotics are still missing. The aim of this mini-review is to give a short overview of some, but not all, adjuvant therapeutic strategies for pneumonia and its most important complications, sepsis and acute respiratory distress syndrome, and briefly discuss future perspectives. European Respiratory Society 2015-09 /pmc/articles/PMC9487679/ /pubmed/26324814 http://dx.doi.org/10.1183/16000617.0034-2015 Text en Copyright ©ERS 2015. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Lung Science Conference Müller-Redetzky, Holger Lienau, Jasmin Suttorp, Norbert Witzenrath, Martin Therapeutic strategies in pneumonia: going beyond antibiotics |
title | Therapeutic strategies in pneumonia: going beyond antibiotics |
title_full | Therapeutic strategies in pneumonia: going beyond antibiotics |
title_fullStr | Therapeutic strategies in pneumonia: going beyond antibiotics |
title_full_unstemmed | Therapeutic strategies in pneumonia: going beyond antibiotics |
title_short | Therapeutic strategies in pneumonia: going beyond antibiotics |
title_sort | therapeutic strategies in pneumonia: going beyond antibiotics |
topic | Lung Science Conference |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487679/ https://www.ncbi.nlm.nih.gov/pubmed/26324814 http://dx.doi.org/10.1183/16000617.0034-2015 |
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