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Therapeutic strategies in pneumonia: going beyond antibiotics

Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therape...

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Autores principales: Müller-Redetzky, Holger, Lienau, Jasmin, Suttorp, Norbert, Witzenrath, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487679/
https://www.ncbi.nlm.nih.gov/pubmed/26324814
http://dx.doi.org/10.1183/16000617.0034-2015
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author Müller-Redetzky, Holger
Lienau, Jasmin
Suttorp, Norbert
Witzenrath, Martin
author_facet Müller-Redetzky, Holger
Lienau, Jasmin
Suttorp, Norbert
Witzenrath, Martin
author_sort Müller-Redetzky, Holger
collection PubMed
description Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therapeutic targets have been identified and numerous innovative therapeutic approaches demonstrated to improve lung injury in experimental preclinical studies. However, at present specific preventive or curative strategies for the treatment of lung failure in pneumonia in addition to antibiotics are still missing. The aim of this mini-review is to give a short overview of some, but not all, adjuvant therapeutic strategies for pneumonia and its most important complications, sepsis and acute respiratory distress syndrome, and briefly discuss future perspectives.
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spelling pubmed-94876792022-11-14 Therapeutic strategies in pneumonia: going beyond antibiotics Müller-Redetzky, Holger Lienau, Jasmin Suttorp, Norbert Witzenrath, Martin Eur Respir Rev Lung Science Conference Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therapeutic targets have been identified and numerous innovative therapeutic approaches demonstrated to improve lung injury in experimental preclinical studies. However, at present specific preventive or curative strategies for the treatment of lung failure in pneumonia in addition to antibiotics are still missing. The aim of this mini-review is to give a short overview of some, but not all, adjuvant therapeutic strategies for pneumonia and its most important complications, sepsis and acute respiratory distress syndrome, and briefly discuss future perspectives. European Respiratory Society 2015-09 /pmc/articles/PMC9487679/ /pubmed/26324814 http://dx.doi.org/10.1183/16000617.0034-2015 Text en Copyright ©ERS 2015. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Lung Science Conference
Müller-Redetzky, Holger
Lienau, Jasmin
Suttorp, Norbert
Witzenrath, Martin
Therapeutic strategies in pneumonia: going beyond antibiotics
title Therapeutic strategies in pneumonia: going beyond antibiotics
title_full Therapeutic strategies in pneumonia: going beyond antibiotics
title_fullStr Therapeutic strategies in pneumonia: going beyond antibiotics
title_full_unstemmed Therapeutic strategies in pneumonia: going beyond antibiotics
title_short Therapeutic strategies in pneumonia: going beyond antibiotics
title_sort therapeutic strategies in pneumonia: going beyond antibiotics
topic Lung Science Conference
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487679/
https://www.ncbi.nlm.nih.gov/pubmed/26324814
http://dx.doi.org/10.1183/16000617.0034-2015
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