Cargando…

Therapeutic strategies in pneumonia: going beyond antibiotics

Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therape...

Descripción completa

Detalles Bibliográficos
Autores principales:	Müller-Redetzky, Holger, Lienau, Jasmin, Suttorp, Norbert, Witzenrath, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2015
Materias:	Lung Science Conference
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487679/ https://www.ncbi.nlm.nih.gov/pubmed/26324814 http://dx.doi.org/10.1183/16000617.0034-2015

Ejemplares similares

Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives
por: Müller-Redetzky, Holger C., et al.
Publicado: (2014)

The Lung Endothelial Barrier in Acute Inflammation
por: Müller-Redetzky, Holger C., et al.
Publicado: (2015)

Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice
por: Wienhold, Sandra-Maria, et al.
Publicado: (2018)

Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens
por: Vandeplassche, Eva, et al.
Publicado: (2019)

Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia
por: Berger, Sarah, et al.
Publicado: (2018)

Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
por: Robinson, Matthew John, et al.
Publicado: (2020)

Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung mucosal compartments
por: Lai, Rocky, et al.
Publicado: (2015)

Matrix abnormalities in pulmonary fibrosis
por: Upagupta, Chandak, et al.
Publicado: (2018)

Neues zur Pathophysiologie der Pneumonie
por: Hippenstiel, S., et al.
Publicado: (2007)

Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin
por: Müller-Redetzky, Holger C, et al.
Publicado: (2014)

Macrophage adaptation in airway inflammatory resolution
por: Kaur, Manminder, et al.
Publicado: (2015)

The heterogeneity of lung macrophages in the susceptibility to disease
por: Morales-Nebreda, Luisa, et al.
Publicado: (2015)

Intersections of lung progenitor cells, lung disease and lung cancer
por: Kim, Carla F.
Publicado: (2017)

Cell therapy for lung disease
por: Geiger, Sabine, et al.
Publicado: (2017)

Immune checkpoints in chronic obstructive pulmonary disease
por: Wilkinson, Tom M.A.
Publicado: (2017)

Shared epithelial pathways to lung repair and disease
por: Spella, Magda, et al.
Publicado: (2017)

Acellular human lung scaffolds to model lung disease and tissue regeneration
por: Gilpin, Sarah E., et al.
Publicado: (2018)

The exposome concept: a challenge and a potential driver for environmental health research
por: Siroux, Valérie, et al.
Publicado: (2016)

Natural experiments and large databases in respiratory and cardiovascular disease
por: Vestbo, Jørgen
Publicado: (2016)

Epigenetic mechanisms in pulmonary arterial hypertension: the need for global perspectives
por: Chelladurai, Prakash, et al.
Publicado: (2016)

The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
por: Patel, Dhiren F., et al.
Publicado: (2018)

Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment
por: Zheng, Xiang, et al.
Publicado: (2020)

How bacteria hack the matrix and dodge the bullets of immunity
por: Paulsson, Magnus, et al.
Publicado: (2018)

The ageing lung under stress
por: Korfei, Martina, et al.
Publicado: (2020)

Endoplasmic reticulum stress in lung disease
por: Marciniak, Stefan J.
Publicado: (2017)

Mitochondrial dysfunction in lung ageing and disease
por: Cloonan, Suzanne M., et al.
Publicado: (2020)

Respiratory muscle senescence in ageing and chronic lung diseases
por: Gea, Joaquim, et al.
Publicado: (2020)

The consequence of matrix dysfunction on lung immunity and the microbiome in COPD
por: Hussell, Tracy, et al.
Publicado: (2018)

The contribution of infection and the respiratory microbiome in acute exacerbations of idiopathic pulmonary fibrosis
por: Invernizzi, Rachele, et al.
Publicado: (2019)

Intermedin Stabilized Endothelial Barrier Function and Attenuated Ventilator-induced Lung Injury in Mice
por: Müller-Redetzky, Holger Christian, et al.
Publicado: (2012)

A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection
por: Schirm, Sibylle, et al.
Publicado: (2020)

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia
por: Gutbier, Birgitt, et al.
Publicado: (2017)

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice
por: Müller-Redetzky, Holger C, et al.
Publicado: (2015)

Towards Inhaled Phage Therapy in Western Europe
por: Wienhold, Sandra-Maria, et al.
Publicado: (2019)

Chronic lung diseases: entangled in extracellular matrix
por: Burgess, Janette K., et al.
Publicado: (2022)

Optimal resection rate for lung cancer in the UK: how high should we go?
por: Belcher, Elizabeth, et al.
Publicado: (2021)

The microbiome in bronchiectasis
por: Richardson, Hollian, et al.
Publicado: (2019)

A role for club cells in smoking-associated lung adenocarcinoma
por: Behrend, Sabine J., et al.
Publicado: (2021)

Particulate matter and the airway epithelium: the special case of the underground?
por: Cooper, Dawn M., et al.
Publicado: (2019)

Cellular mechanisms underlying steroid-resistant asthma
por: Wadhwa, Ridhima, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_eg3a2995r42c07gmt2i7ekgk00