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Macrophage adaptation in airway inflammatory resolution
Bacterial and viral infections (exacerbations) are particularly problematic in those with underlying respiratory disease, including post-viral infection, asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. Patients experiencing exacerbations tend to be at the more severe end of the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487683/ https://www.ncbi.nlm.nih.gov/pubmed/26324813 http://dx.doi.org/10.1183/16000617.0030-2015 |
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author | Kaur, Manminder Bell, Thomas Salek-Ardakani, Samira Hussell, Tracy |
author_facet | Kaur, Manminder Bell, Thomas Salek-Ardakani, Samira Hussell, Tracy |
author_sort | Kaur, Manminder |
collection | PubMed |
description | Bacterial and viral infections (exacerbations) are particularly problematic in those with underlying respiratory disease, including post-viral infection, asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. Patients experiencing exacerbations tend to be at the more severe end of the disease spectrum and are often difficult to treat. Most of the unmet medical need remains in this patient group. Airway macrophages are one of the first cell populations to encounter airborne pathogens and, in health, exist in a state of reduced responsiveness due to interactions with the respiratory epithelium and specific factors found in the airway lumen. Granulocyte–macrophage colony-stimulating factor, interleukin-10, transforming growth factor-β, surfactant proteins and signalling via the CD200 receptor, for example, all raise the threshold above which airway macrophages can be activated. We highlight that following severe respiratory inflammation, the airspace microenvironment does not automatically re-set to baseline and may leave airway macrophages more restrained than they were at the outset. This excessive restraint is mediated in part by the clearance of apoptotic cells and components of extracellular matrix. This implies that one strategy to combat respiratory exacerbations would be to retune airway macrophage responsiveness to allow earlier bacterial recognition. |
format | Online Article Text |
id | pubmed-9487683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94876832022-11-14 Macrophage adaptation in airway inflammatory resolution Kaur, Manminder Bell, Thomas Salek-Ardakani, Samira Hussell, Tracy Eur Respir Rev Lung Science Conference Bacterial and viral infections (exacerbations) are particularly problematic in those with underlying respiratory disease, including post-viral infection, asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. Patients experiencing exacerbations tend to be at the more severe end of the disease spectrum and are often difficult to treat. Most of the unmet medical need remains in this patient group. Airway macrophages are one of the first cell populations to encounter airborne pathogens and, in health, exist in a state of reduced responsiveness due to interactions with the respiratory epithelium and specific factors found in the airway lumen. Granulocyte–macrophage colony-stimulating factor, interleukin-10, transforming growth factor-β, surfactant proteins and signalling via the CD200 receptor, for example, all raise the threshold above which airway macrophages can be activated. We highlight that following severe respiratory inflammation, the airspace microenvironment does not automatically re-set to baseline and may leave airway macrophages more restrained than they were at the outset. This excessive restraint is mediated in part by the clearance of apoptotic cells and components of extracellular matrix. This implies that one strategy to combat respiratory exacerbations would be to retune airway macrophage responsiveness to allow earlier bacterial recognition. European Respiratory Society 2015-09 /pmc/articles/PMC9487683/ /pubmed/26324813 http://dx.doi.org/10.1183/16000617.0030-2015 Text en Copyright ©ERS 2015. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Lung Science Conference Kaur, Manminder Bell, Thomas Salek-Ardakani, Samira Hussell, Tracy Macrophage adaptation in airway inflammatory resolution |
title | Macrophage adaptation in airway inflammatory resolution |
title_full | Macrophage adaptation in airway inflammatory resolution |
title_fullStr | Macrophage adaptation in airway inflammatory resolution |
title_full_unstemmed | Macrophage adaptation in airway inflammatory resolution |
title_short | Macrophage adaptation in airway inflammatory resolution |
title_sort | macrophage adaptation in airway inflammatory resolution |
topic | Lung Science Conference |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487683/ https://www.ncbi.nlm.nih.gov/pubmed/26324813 http://dx.doi.org/10.1183/16000617.0030-2015 |
work_keys_str_mv | AT kaurmanminder macrophageadaptationinairwayinflammatoryresolution AT bellthomas macrophageadaptationinairwayinflammatoryresolution AT salekardakanisamira macrophageadaptationinairwayinflammatoryresolution AT husselltracy macrophageadaptationinairwayinflammatoryresolution |