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Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, Sleggs and Marchand from South Africa linked asbestos to mesothelioma, paving...

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Detalles Bibliográficos
Autores principales: Røe, Oluf Dimitri, Stella, Giulia Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487774/
https://www.ncbi.nlm.nih.gov/pubmed/25726562
http://dx.doi.org/10.1183/09059180.00007014
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author Røe, Oluf Dimitri
Stella, Giulia Maria
author_facet Røe, Oluf Dimitri
Stella, Giulia Maria
author_sort Røe, Oluf Dimitri
collection PubMed
description Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, Sleggs and Marchand from South Africa linked asbestos to mesothelioma, paving the way to the current knowledge of the aetiology, epidemiology and biology of malignant pleural mesothelioma. Pleural mesothelioma is one of the most lethal cancers, with increasing incidence worldwide. This review will give some snapshots of the history of pleural mesothelioma discovery, and the body of epidemiological and biological research, including some of the controversies and unresolved questions. Translational research is currently unravelling novel circulating biomarkers for earlier diagnosis and novel treatment targets. Current breakthrough discoveries of clinically promising noninvasive biomarkers, such as the 13-protein signature, microRNAs and the BAP1 mesothelioma/cancer syndrome, are highlighted. The asbestos history is a lesson to not be repeated, but here we also review recent in vivo and in vitro studies showing that manmade carbon nanofibres could pose a similar danger to human health. This should be taken seriously by regulatory bodies to ensure thorough testing of novel materials before release in the society.
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spelling pubmed-94877742022-11-14 Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic Røe, Oluf Dimitri Stella, Giulia Maria Eur Respir Rev Reviews Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, Sleggs and Marchand from South Africa linked asbestos to mesothelioma, paving the way to the current knowledge of the aetiology, epidemiology and biology of malignant pleural mesothelioma. Pleural mesothelioma is one of the most lethal cancers, with increasing incidence worldwide. This review will give some snapshots of the history of pleural mesothelioma discovery, and the body of epidemiological and biological research, including some of the controversies and unresolved questions. Translational research is currently unravelling novel circulating biomarkers for earlier diagnosis and novel treatment targets. Current breakthrough discoveries of clinically promising noninvasive biomarkers, such as the 13-protein signature, microRNAs and the BAP1 mesothelioma/cancer syndrome, are highlighted. The asbestos history is a lesson to not be repeated, but here we also review recent in vivo and in vitro studies showing that manmade carbon nanofibres could pose a similar danger to human health. This should be taken seriously by regulatory bodies to ensure thorough testing of novel materials before release in the society. European Respiratory Society 2015-03 /pmc/articles/PMC9487774/ /pubmed/25726562 http://dx.doi.org/10.1183/09059180.00007014 Text en Copyright ©ERS 2015. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Reviews
Røe, Oluf Dimitri
Stella, Giulia Maria
Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic
title Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic
title_full Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic
title_fullStr Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic
title_full_unstemmed Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic
title_short Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic
title_sort malignant pleural mesothelioma: history, controversy and future of a manmade epidemic
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487774/
https://www.ncbi.nlm.nih.gov/pubmed/25726562
http://dx.doi.org/10.1183/09059180.00007014
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