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Identifying the outcomes important to men with hypogonadism: A qualitative evidence synthesis

OBJECTIVE: Men with male hypogonadism (MH) experience sexual dysfunction, which improves with testosterone replacement therapy (TRT). However, randomised controlled trials provide little consensus on functional and behavioural symptoms in hypogonadal men; these are often better captured by qualitati...

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Autores principales: Aceves‐Martins, Magaly, Quinton, Richard, Brazzelli, Miriam, Cruickshank, Moira, Manson, Paul, Hudson, Jemma, Oliver, Nick, Hernandez, Rodolfo, Aucott, Lorna, Wu, Frederick, Dhillo, Waljit S., Bhattacharya, Siladitya, Gillies, Katie, Jayasena, Channa N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487983/
https://www.ncbi.nlm.nih.gov/pubmed/35064779
http://dx.doi.org/10.1111/andr.13156
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author Aceves‐Martins, Magaly
Quinton, Richard
Brazzelli, Miriam
Cruickshank, Moira
Manson, Paul
Hudson, Jemma
Oliver, Nick
Hernandez, Rodolfo
Aucott, Lorna
Wu, Frederick
Dhillo, Waljit S.
Bhattacharya, Siladitya
Gillies, Katie
Jayasena, Channa N.
author_facet Aceves‐Martins, Magaly
Quinton, Richard
Brazzelli, Miriam
Cruickshank, Moira
Manson, Paul
Hudson, Jemma
Oliver, Nick
Hernandez, Rodolfo
Aucott, Lorna
Wu, Frederick
Dhillo, Waljit S.
Bhattacharya, Siladitya
Gillies, Katie
Jayasena, Channa N.
author_sort Aceves‐Martins, Magaly
collection PubMed
description OBJECTIVE: Men with male hypogonadism (MH) experience sexual dysfunction, which improves with testosterone replacement therapy (TRT). However, randomised controlled trials provide little consensus on functional and behavioural symptoms in hypogonadal men; these are often better captured by qualitative information from individual patient experience. METHODS: We systematically searched major electronic databases to identify qualitative data from men with hypogonadism, with or without TRT. Two independent authors performed the selection, extraction, and thematic analysis of data. Quality of eligible studies was assessed using the Critical Appraisals Skills Programme and Grading of Recommendations Assessment, Development and Evaluation‐Confidence in the Evidence from Reviews of Qualitative research tools. RESULTS: We analysed data from five studies published in nine reports that assessed a total of 284 participants. Published data were only available within North America, with no ethnic minority or other underserved groups included. In addition to sexual dysfunction, men with MH experienced adverse changes in physical strength, perceptions of masculinity, cognitive function, and quality of life. The experience of MH appeared dependent on the source(s) of educational material. DISCUSSION: We propose a patient‐centred approach to clinician interactions rather than focusing on discreet MH symptoms. Current evidence about the experience of MH is limited to North America and predominantly white ethnicity, which may not be broadly applicable to other geographic regions. Broadening our understanding of the MH experience may improve the targeting of information to patients. In addition, a multidisciplinary approach may better address symptoms neither attributable to MH nor alleviated by TRT.
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spelling pubmed-94879832022-09-30 Identifying the outcomes important to men with hypogonadism: A qualitative evidence synthesis Aceves‐Martins, Magaly Quinton, Richard Brazzelli, Miriam Cruickshank, Moira Manson, Paul Hudson, Jemma Oliver, Nick Hernandez, Rodolfo Aucott, Lorna Wu, Frederick Dhillo, Waljit S. Bhattacharya, Siladitya Gillies, Katie Jayasena, Channa N. Andrology Review Articles OBJECTIVE: Men with male hypogonadism (MH) experience sexual dysfunction, which improves with testosterone replacement therapy (TRT). However, randomised controlled trials provide little consensus on functional and behavioural symptoms in hypogonadal men; these are often better captured by qualitative information from individual patient experience. METHODS: We systematically searched major electronic databases to identify qualitative data from men with hypogonadism, with or without TRT. Two independent authors performed the selection, extraction, and thematic analysis of data. Quality of eligible studies was assessed using the Critical Appraisals Skills Programme and Grading of Recommendations Assessment, Development and Evaluation‐Confidence in the Evidence from Reviews of Qualitative research tools. RESULTS: We analysed data from five studies published in nine reports that assessed a total of 284 participants. Published data were only available within North America, with no ethnic minority or other underserved groups included. In addition to sexual dysfunction, men with MH experienced adverse changes in physical strength, perceptions of masculinity, cognitive function, and quality of life. The experience of MH appeared dependent on the source(s) of educational material. DISCUSSION: We propose a patient‐centred approach to clinician interactions rather than focusing on discreet MH symptoms. Current evidence about the experience of MH is limited to North America and predominantly white ethnicity, which may not be broadly applicable to other geographic regions. Broadening our understanding of the MH experience may improve the targeting of information to patients. In addition, a multidisciplinary approach may better address symptoms neither attributable to MH nor alleviated by TRT. John Wiley and Sons Inc. 2022-02-08 2022-05 /pmc/articles/PMC9487983/ /pubmed/35064779 http://dx.doi.org/10.1111/andr.13156 Text en © 2022 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Aceves‐Martins, Magaly
Quinton, Richard
Brazzelli, Miriam
Cruickshank, Moira
Manson, Paul
Hudson, Jemma
Oliver, Nick
Hernandez, Rodolfo
Aucott, Lorna
Wu, Frederick
Dhillo, Waljit S.
Bhattacharya, Siladitya
Gillies, Katie
Jayasena, Channa N.
Identifying the outcomes important to men with hypogonadism: A qualitative evidence synthesis
title Identifying the outcomes important to men with hypogonadism: A qualitative evidence synthesis
title_full Identifying the outcomes important to men with hypogonadism: A qualitative evidence synthesis
title_fullStr Identifying the outcomes important to men with hypogonadism: A qualitative evidence synthesis
title_full_unstemmed Identifying the outcomes important to men with hypogonadism: A qualitative evidence synthesis
title_short Identifying the outcomes important to men with hypogonadism: A qualitative evidence synthesis
title_sort identifying the outcomes important to men with hypogonadism: a qualitative evidence synthesis
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487983/
https://www.ncbi.nlm.nih.gov/pubmed/35064779
http://dx.doi.org/10.1111/andr.13156
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