Contributions of sex and genotype to exploratory behavior differences in an aged humanized APOE mouse model of late-onset Alzheimer's disease

Age, genetics, and chromosomal sex have been identified as critical risk factors for late-onset Alzheimer's disease (LOAD). The predominant genetic risk factor for LOAD is the apolipoprotein E ε4 allele (APOE4), and the prevalence of LOAD is higher in females. However, the translational validit...

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Detalles Bibliográficos
Autores principales: McLean, John W., Bhattrai, Avnish, Vitali, Francesca, Raikes, Adam C., Wiegand, Jean-Paul L., Brinton, Roberta Diaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488030/
https://www.ncbi.nlm.nih.gov/pubmed/36206387
http://dx.doi.org/10.1101/lm.053588.122

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