Elevated IL-18 predicts poor prognosis in critically ill COVID-19 patients at a Brazilian hospital in 2020–21

Background: A dysregulated inflammatory response contributes to decline in patients with COVID-19. This cross-sectional study evaluated biomarkers of unvaccinated patients admitted to the intensive care unit of a hospital in Fortaleza, Brazil. Methods: Twenty cytokines were quantified upon hospital...

Descripción completa

Detalles Bibliográficos
Autores principales: Coutinho, Lucyana LC, Oliveira, Caroline N, Albuquerque, Polianna LMM, Mota, Sandra MB, Meneses, Gdayllon C, Martins, Alice MC, Junior, Geraldo BS, Clementino, Marco AF, Gondim, Rafhaella NDG, Havt, Alexandre, Cavalcanti, Luciano PG, Yaochite, Juliana NU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488117/
https://www.ncbi.nlm.nih.gov/pubmed/36111789
http://dx.doi.org/10.2217/fmb-2022-0057
Descripción
Sumario:Background: A dysregulated inflammatory response contributes to decline in patients with COVID-19. This cross-sectional study evaluated biomarkers of unvaccinated patients admitted to the intensive care unit of a hospital in Fortaleza, Brazil. Methods: Twenty cytokines were quantified upon hospital admission; clinical and laboratory data were analyzed, as well as sociodemographic data, to search for an association with clinical outcomes, including fatal (n = 40) or recovered cases (n = 38). Results: Fatal cases exhibited significantly higher levels of IL-18 (p = 0.009); deceased patients were older (p = 0.0001), had a lower number of platelets (p = 0.0063) and higher neutrophil–lymphocyte ratio (p = 0.0230) than those who recovered. Conclusion: These findings indicate that IL-18 is a possible marker to predict poor prognosis in critically ill patients with COVID-19.

Ejemplares similares