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Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD
Chronic obstructive pulmonary disease (COPD) is currently the third most common cause of global mortality. Acute exacerbations of COPD frequently necessitate hospital admission to enable more intensive therapy, incurring significant healthcare costs. COPD exacerbations are also associated with accel...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488189/ https://www.ncbi.nlm.nih.gov/pubmed/30872396 http://dx.doi.org/10.1183/16000617.0063-2018 |
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author | Linden, Dermot Guo-Parke, Hong Coyle, Peter V. Fairley, Derek McAuley, Danny F. Taggart, Clifford C. Kidney, Joe |
author_facet | Linden, Dermot Guo-Parke, Hong Coyle, Peter V. Fairley, Derek McAuley, Danny F. Taggart, Clifford C. Kidney, Joe |
author_sort | Linden, Dermot |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) is currently the third most common cause of global mortality. Acute exacerbations of COPD frequently necessitate hospital admission to enable more intensive therapy, incurring significant healthcare costs. COPD exacerbations are also associated with accelerated lung function decline and increased risk of mortality. Until recently, bacterial pathogens were believed to be responsible for the majority of disease exacerbations. However, with the advent of culture-independent molecular diagnostic techniques it is now estimated that viruses are detected during half of all COPD exacerbations and are associated with poorer clinical outcomes. Human rhinovirus, respiratory syncytial virus and influenza are the most commonly detected viruses during exacerbation. The role of persistent viral infection (adenovirus) has also been postulated as a potential pathogenic mechanism in COPD. Viral pathogens may play an important role in driving COPD progression by acting as triggers for exacerbation and subsequent lung function decline whilst the role of chronic viral infection remains a plausible hypothesis that requires further evaluation. There are currently no effective antiviral strategies for patients with COPD. Herein, we focus on the current understanding of the cellular and molecular mechanisms of respiratory viral infection in COPD. |
format | Online Article Text |
id | pubmed-9488189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94881892022-11-14 Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD Linden, Dermot Guo-Parke, Hong Coyle, Peter V. Fairley, Derek McAuley, Danny F. Taggart, Clifford C. Kidney, Joe Eur Respir Rev Review Chronic obstructive pulmonary disease (COPD) is currently the third most common cause of global mortality. Acute exacerbations of COPD frequently necessitate hospital admission to enable more intensive therapy, incurring significant healthcare costs. COPD exacerbations are also associated with accelerated lung function decline and increased risk of mortality. Until recently, bacterial pathogens were believed to be responsible for the majority of disease exacerbations. However, with the advent of culture-independent molecular diagnostic techniques it is now estimated that viruses are detected during half of all COPD exacerbations and are associated with poorer clinical outcomes. Human rhinovirus, respiratory syncytial virus and influenza are the most commonly detected viruses during exacerbation. The role of persistent viral infection (adenovirus) has also been postulated as a potential pathogenic mechanism in COPD. Viral pathogens may play an important role in driving COPD progression by acting as triggers for exacerbation and subsequent lung function decline whilst the role of chronic viral infection remains a plausible hypothesis that requires further evaluation. There are currently no effective antiviral strategies for patients with COPD. Herein, we focus on the current understanding of the cellular and molecular mechanisms of respiratory viral infection in COPD. European Respiratory Society 2019-03-13 /pmc/articles/PMC9488189/ /pubmed/30872396 http://dx.doi.org/10.1183/16000617.0063-2018 Text en Copyright ©ERS 2019. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Review Linden, Dermot Guo-Parke, Hong Coyle, Peter V. Fairley, Derek McAuley, Danny F. Taggart, Clifford C. Kidney, Joe Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD |
title | Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD |
title_full | Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD |
title_fullStr | Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD |
title_full_unstemmed | Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD |
title_short | Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD |
title_sort | respiratory viral infection: a potential “missing link” in the pathogenesis of copd |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488189/ https://www.ncbi.nlm.nih.gov/pubmed/30872396 http://dx.doi.org/10.1183/16000617.0063-2018 |
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