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Early origins of lung disease: towards an interdisciplinary approach
The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respirat...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488517/ https://www.ncbi.nlm.nih.gov/pubmed/33004528 http://dx.doi.org/10.1183/16000617.0191-2020 |
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author | Ubags, Niki D.J. Alejandre Alcazar, Miguel A. Kallapur, Suhas G. Knapp, Sylvia Lanone, Sophie Lloyd, Clare M. Morty, Rory E. Pattaroni, Céline Reynaert, Niki L. Rottier, Robbert J. Smits, Hermelijn H. de Steenhuijsen Piters, Wouter A.A. Strickland, Deborah H. Collins, Jennifer J.P. |
author_facet | Ubags, Niki D.J. Alejandre Alcazar, Miguel A. Kallapur, Suhas G. Knapp, Sylvia Lanone, Sophie Lloyd, Clare M. Morty, Rory E. Pattaroni, Céline Reynaert, Niki L. Rottier, Robbert J. Smits, Hermelijn H. de Steenhuijsen Piters, Wouter A.A. Strickland, Deborah H. Collins, Jennifer J.P. |
author_sort | Ubags, Niki D.J. |
collection | PubMed |
description | The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and immune maturation on the development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time point are detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the European Respiratory Society Research Seminar “Early origins of lung disease: towards an interdisciplinary approach” (Lisbon, Portugal, November 2019). |
format | Online Article Text |
id | pubmed-9488517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94885172022-11-14 Early origins of lung disease: towards an interdisciplinary approach Ubags, Niki D.J. Alejandre Alcazar, Miguel A. Kallapur, Suhas G. Knapp, Sylvia Lanone, Sophie Lloyd, Clare M. Morty, Rory E. Pattaroni, Céline Reynaert, Niki L. Rottier, Robbert J. Smits, Hermelijn H. de Steenhuijsen Piters, Wouter A.A. Strickland, Deborah H. Collins, Jennifer J.P. Eur Respir Rev Assembly 3 Reviews The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and immune maturation on the development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time point are detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the European Respiratory Society Research Seminar “Early origins of lung disease: towards an interdisciplinary approach” (Lisbon, Portugal, November 2019). European Respiratory Society 2020-10-01 /pmc/articles/PMC9488517/ /pubmed/33004528 http://dx.doi.org/10.1183/16000617.0191-2020 Text en Copyright ©ERS 2020. https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Assembly 3 Reviews Ubags, Niki D.J. Alejandre Alcazar, Miguel A. Kallapur, Suhas G. Knapp, Sylvia Lanone, Sophie Lloyd, Clare M. Morty, Rory E. Pattaroni, Céline Reynaert, Niki L. Rottier, Robbert J. Smits, Hermelijn H. de Steenhuijsen Piters, Wouter A.A. Strickland, Deborah H. Collins, Jennifer J.P. Early origins of lung disease: towards an interdisciplinary approach |
title | Early origins of lung disease: towards an interdisciplinary approach |
title_full | Early origins of lung disease: towards an interdisciplinary approach |
title_fullStr | Early origins of lung disease: towards an interdisciplinary approach |
title_full_unstemmed | Early origins of lung disease: towards an interdisciplinary approach |
title_short | Early origins of lung disease: towards an interdisciplinary approach |
title_sort | early origins of lung disease: towards an interdisciplinary approach |
topic | Assembly 3 Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488517/ https://www.ncbi.nlm.nih.gov/pubmed/33004528 http://dx.doi.org/10.1183/16000617.0191-2020 |
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