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Early origins of lung disease: towards an interdisciplinary approach

The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respirat...

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Autores principales: Ubags, Niki D.J., Alejandre Alcazar, Miguel A., Kallapur, Suhas G., Knapp, Sylvia, Lanone, Sophie, Lloyd, Clare M., Morty, Rory E., Pattaroni, Céline, Reynaert, Niki L., Rottier, Robbert J., Smits, Hermelijn H., de Steenhuijsen Piters, Wouter A.A., Strickland, Deborah H., Collins, Jennifer J.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488517/
https://www.ncbi.nlm.nih.gov/pubmed/33004528
http://dx.doi.org/10.1183/16000617.0191-2020
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author Ubags, Niki D.J.
Alejandre Alcazar, Miguel A.
Kallapur, Suhas G.
Knapp, Sylvia
Lanone, Sophie
Lloyd, Clare M.
Morty, Rory E.
Pattaroni, Céline
Reynaert, Niki L.
Rottier, Robbert J.
Smits, Hermelijn H.
de Steenhuijsen Piters, Wouter A.A.
Strickland, Deborah H.
Collins, Jennifer J.P.
author_facet Ubags, Niki D.J.
Alejandre Alcazar, Miguel A.
Kallapur, Suhas G.
Knapp, Sylvia
Lanone, Sophie
Lloyd, Clare M.
Morty, Rory E.
Pattaroni, Céline
Reynaert, Niki L.
Rottier, Robbert J.
Smits, Hermelijn H.
de Steenhuijsen Piters, Wouter A.A.
Strickland, Deborah H.
Collins, Jennifer J.P.
author_sort Ubags, Niki D.J.
collection PubMed
description The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and immune maturation on the development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time point are detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the European Respiratory Society Research Seminar “Early origins of lung disease: towards an interdisciplinary approach” (Lisbon, Portugal, November 2019).
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spelling pubmed-94885172022-11-14 Early origins of lung disease: towards an interdisciplinary approach Ubags, Niki D.J. Alejandre Alcazar, Miguel A. Kallapur, Suhas G. Knapp, Sylvia Lanone, Sophie Lloyd, Clare M. Morty, Rory E. Pattaroni, Céline Reynaert, Niki L. Rottier, Robbert J. Smits, Hermelijn H. de Steenhuijsen Piters, Wouter A.A. Strickland, Deborah H. Collins, Jennifer J.P. Eur Respir Rev Assembly 3 Reviews The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and immune maturation on the development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time point are detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the European Respiratory Society Research Seminar “Early origins of lung disease: towards an interdisciplinary approach” (Lisbon, Portugal, November 2019). European Respiratory Society 2020-10-01 /pmc/articles/PMC9488517/ /pubmed/33004528 http://dx.doi.org/10.1183/16000617.0191-2020 Text en Copyright ©ERS 2020. https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Assembly 3 Reviews
Ubags, Niki D.J.
Alejandre Alcazar, Miguel A.
Kallapur, Suhas G.
Knapp, Sylvia
Lanone, Sophie
Lloyd, Clare M.
Morty, Rory E.
Pattaroni, Céline
Reynaert, Niki L.
Rottier, Robbert J.
Smits, Hermelijn H.
de Steenhuijsen Piters, Wouter A.A.
Strickland, Deborah H.
Collins, Jennifer J.P.
Early origins of lung disease: towards an interdisciplinary approach
title Early origins of lung disease: towards an interdisciplinary approach
title_full Early origins of lung disease: towards an interdisciplinary approach
title_fullStr Early origins of lung disease: towards an interdisciplinary approach
title_full_unstemmed Early origins of lung disease: towards an interdisciplinary approach
title_short Early origins of lung disease: towards an interdisciplinary approach
title_sort early origins of lung disease: towards an interdisciplinary approach
topic Assembly 3 Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488517/
https://www.ncbi.nlm.nih.gov/pubmed/33004528
http://dx.doi.org/10.1183/16000617.0191-2020
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