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Case report: Rare lung disease of infancy diagnosed with the assistance of a home pulse oximetry baby monitor

Neuroendocrine cell hyperplasia of infancy (NEHI) is a rare childhood interstitial lung disease characterized by a gradual onset of tachypnea, hypoxemia, and failure to thrive in the first 2 years of life. NEHI is challenging to diagnose and can masquerade as common respiratory infections and reacti...

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Autores principales: Yang, Kevin H., Kulatti, Art, Sherer, Kimberly, Rao, Aparna, Cernelc-Kohan, Mateja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488520/
https://www.ncbi.nlm.nih.gov/pubmed/36147808
http://dx.doi.org/10.3389/fped.2022.918764
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author Yang, Kevin H.
Kulatti, Art
Sherer, Kimberly
Rao, Aparna
Cernelc-Kohan, Mateja
author_facet Yang, Kevin H.
Kulatti, Art
Sherer, Kimberly
Rao, Aparna
Cernelc-Kohan, Mateja
author_sort Yang, Kevin H.
collection PubMed
description Neuroendocrine cell hyperplasia of infancy (NEHI) is a rare childhood interstitial lung disease characterized by a gradual onset of tachypnea, hypoxemia, and failure to thrive in the first 2 years of life. NEHI is challenging to diagnose and can masquerade as common respiratory infections and reactive airway disease. Timely diagnosis is essential to optimize management of comorbidities, improve outcomes, and prevent unnecessary interventions. We report a case of a 14-month-old male who was hospitalized multiple times with recurrent episodes of presumed bronchiolitis. However, early on, the parents had detected unexplained nighttime hypoxemia with a wearable home pulse oximetry baby monitor. While recurrent respiratory infections are common in infancy, our patient had numerous persistent symptoms refractory to traditional treatments, which prompted further workup and ultimately led to the diagnosis of NEHI. The home baby monitor provided useful information that accelerated workup for a presentation that did not fit the usual picture of recurrent bronchiolitis, bronchospasm, or pneumonia. These devices that monitor infant cardiopulmonary status and oxygenation are becoming increasingly popular for home use. There is controversy over their clinical utility due to the frequency of false alarms, excessive parental reliance on these devices, and lack of Food and Drug Administration oversight to ensure accuracy and effectiveness of these devices. Our case provides an example of how in certain clinical settings, information from these devices might serve as a complementary tool in the pediatrician’s medical decision-making and possibly lead to a rare diagnosis such as NEHI.
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spelling pubmed-94885202022-09-21 Case report: Rare lung disease of infancy diagnosed with the assistance of a home pulse oximetry baby monitor Yang, Kevin H. Kulatti, Art Sherer, Kimberly Rao, Aparna Cernelc-Kohan, Mateja Front Pediatr Pediatrics Neuroendocrine cell hyperplasia of infancy (NEHI) is a rare childhood interstitial lung disease characterized by a gradual onset of tachypnea, hypoxemia, and failure to thrive in the first 2 years of life. NEHI is challenging to diagnose and can masquerade as common respiratory infections and reactive airway disease. Timely diagnosis is essential to optimize management of comorbidities, improve outcomes, and prevent unnecessary interventions. We report a case of a 14-month-old male who was hospitalized multiple times with recurrent episodes of presumed bronchiolitis. However, early on, the parents had detected unexplained nighttime hypoxemia with a wearable home pulse oximetry baby monitor. While recurrent respiratory infections are common in infancy, our patient had numerous persistent symptoms refractory to traditional treatments, which prompted further workup and ultimately led to the diagnosis of NEHI. The home baby monitor provided useful information that accelerated workup for a presentation that did not fit the usual picture of recurrent bronchiolitis, bronchospasm, or pneumonia. These devices that monitor infant cardiopulmonary status and oxygenation are becoming increasingly popular for home use. There is controversy over their clinical utility due to the frequency of false alarms, excessive parental reliance on these devices, and lack of Food and Drug Administration oversight to ensure accuracy and effectiveness of these devices. Our case provides an example of how in certain clinical settings, information from these devices might serve as a complementary tool in the pediatrician’s medical decision-making and possibly lead to a rare diagnosis such as NEHI. Frontiers Media S.A. 2022-09-06 /pmc/articles/PMC9488520/ /pubmed/36147808 http://dx.doi.org/10.3389/fped.2022.918764 Text en Copyright © 2022 Yang, Kulatti, Sherer, Rao and Cernelc-Kohan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Yang, Kevin H.
Kulatti, Art
Sherer, Kimberly
Rao, Aparna
Cernelc-Kohan, Mateja
Case report: Rare lung disease of infancy diagnosed with the assistance of a home pulse oximetry baby monitor
title Case report: Rare lung disease of infancy diagnosed with the assistance of a home pulse oximetry baby monitor
title_full Case report: Rare lung disease of infancy diagnosed with the assistance of a home pulse oximetry baby monitor
title_fullStr Case report: Rare lung disease of infancy diagnosed with the assistance of a home pulse oximetry baby monitor
title_full_unstemmed Case report: Rare lung disease of infancy diagnosed with the assistance of a home pulse oximetry baby monitor
title_short Case report: Rare lung disease of infancy diagnosed with the assistance of a home pulse oximetry baby monitor
title_sort case report: rare lung disease of infancy diagnosed with the assistance of a home pulse oximetry baby monitor
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488520/
https://www.ncbi.nlm.nih.gov/pubmed/36147808
http://dx.doi.org/10.3389/fped.2022.918764
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