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Dismantling the pathophysiology of asthma using imaging

Asthma remains an important disease worldwide, causing high burden to patients and healthcare systems and presenting a need for better management and ultimately prevention and cure. Asthma is a very heterogeneous condition, with many different pathophysiological processes. Better measurement of thos...

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Detalles Bibliográficos
Autores principales: King, Gregory G., Farrow, Catherine E., Chapman, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488525/
https://www.ncbi.nlm.nih.gov/pubmed/30996039
http://dx.doi.org/10.1183/16000617.0111-2018
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author King, Gregory G.
Farrow, Catherine E.
Chapman, David G.
author_facet King, Gregory G.
Farrow, Catherine E.
Chapman, David G.
author_sort King, Gregory G.
collection PubMed
description Asthma remains an important disease worldwide, causing high burden to patients and healthcare systems and presenting a need for better management and ultimately prevention and cure. Asthma is a very heterogeneous condition, with many different pathophysiological processes. Better measurement of those pathophysiological processes are needed to better phenotype disease, and to go beyond the current, highly limited measurements that are currently used: spirometry and symptoms. Sophisticated three-dimensional lung imaging using computed tomography and ventilation imaging (single photon emission computed tomography and positron emission tomography) and magnetic resonance imaging and methods of lung imaging applicable to asthma research are now highly developed. The body of current evidence suggests that abnormalities in structure and ventilatory function measured by imaging are clinically relevant, given their associations with disease severity, exacerbation risk and airflow obstruction. Therefore, lung imaging is ready for more widespread use in clinical trials and to become part of routine clinical assessment of asthma.
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spelling pubmed-94885252022-11-14 Dismantling the pathophysiology of asthma using imaging King, Gregory G. Farrow, Catherine E. Chapman, David G. Eur Respir Rev Series Asthma remains an important disease worldwide, causing high burden to patients and healthcare systems and presenting a need for better management and ultimately prevention and cure. Asthma is a very heterogeneous condition, with many different pathophysiological processes. Better measurement of those pathophysiological processes are needed to better phenotype disease, and to go beyond the current, highly limited measurements that are currently used: spirometry and symptoms. Sophisticated three-dimensional lung imaging using computed tomography and ventilation imaging (single photon emission computed tomography and positron emission tomography) and magnetic resonance imaging and methods of lung imaging applicable to asthma research are now highly developed. The body of current evidence suggests that abnormalities in structure and ventilatory function measured by imaging are clinically relevant, given their associations with disease severity, exacerbation risk and airflow obstruction. Therefore, lung imaging is ready for more widespread use in clinical trials and to become part of routine clinical assessment of asthma. European Respiratory Society 2019-04-17 /pmc/articles/PMC9488525/ /pubmed/30996039 http://dx.doi.org/10.1183/16000617.0111-2018 Text en Copyright ©ERS 2019. https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Series
King, Gregory G.
Farrow, Catherine E.
Chapman, David G.
Dismantling the pathophysiology of asthma using imaging
title Dismantling the pathophysiology of asthma using imaging
title_full Dismantling the pathophysiology of asthma using imaging
title_fullStr Dismantling the pathophysiology of asthma using imaging
title_full_unstemmed Dismantling the pathophysiology of asthma using imaging
title_short Dismantling the pathophysiology of asthma using imaging
title_sort dismantling the pathophysiology of asthma using imaging
topic Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488525/
https://www.ncbi.nlm.nih.gov/pubmed/30996039
http://dx.doi.org/10.1183/16000617.0111-2018
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