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Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) remains a significant source of mortality in critically ill patients. Characterised by acute, widespread alveolar inflammation and pulmonary oedema, its pathophysiological heterogeneity has meant that targeted treatments have remained elusive. Metabolomic a...

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Detalles Bibliográficos
Autores principales: Robinson, Matthew John, Krasnodembskaya, Anna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488567/
https://www.ncbi.nlm.nih.gov/pubmed/32620587
http://dx.doi.org/10.1183/16000617.0114-2020
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author Robinson, Matthew John
Krasnodembskaya, Anna D.
author_facet Robinson, Matthew John
Krasnodembskaya, Anna D.
author_sort Robinson, Matthew John
collection PubMed
description Acute respiratory distress syndrome (ARDS) remains a significant source of mortality in critically ill patients. Characterised by acute, widespread alveolar inflammation and pulmonary oedema, its pathophysiological heterogeneity has meant that targeted treatments have remained elusive. Metabolomic analysis has made initial steps in characterising the underlying metabolic derangements of ARDS as an indicator of phenotypical class and has identified mitochondrial dysfunction as a potential therapeutic target. Mesenchymal stem cells and their derived extracellular vesicles have shown significant promise as potential therapies in delivering mitochondria in order to redivert metabolism onto physiological pathways.
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spelling pubmed-94885672022-11-14 Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome Robinson, Matthew John Krasnodembskaya, Anna D. Eur Respir Rev Lung Science Conference Acute respiratory distress syndrome (ARDS) remains a significant source of mortality in critically ill patients. Characterised by acute, widespread alveolar inflammation and pulmonary oedema, its pathophysiological heterogeneity has meant that targeted treatments have remained elusive. Metabolomic analysis has made initial steps in characterising the underlying metabolic derangements of ARDS as an indicator of phenotypical class and has identified mitochondrial dysfunction as a potential therapeutic target. Mesenchymal stem cells and their derived extracellular vesicles have shown significant promise as potential therapies in delivering mitochondria in order to redivert metabolism onto physiological pathways. European Respiratory Society 2020-07-03 /pmc/articles/PMC9488567/ /pubmed/32620587 http://dx.doi.org/10.1183/16000617.0114-2020 Text en Copyright ©ERS 2020. https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Lung Science Conference
Robinson, Matthew John
Krasnodembskaya, Anna D.
Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
title Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
title_full Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
title_fullStr Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
title_full_unstemmed Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
title_short Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
title_sort therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
topic Lung Science Conference
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488567/
https://www.ncbi.nlm.nih.gov/pubmed/32620587
http://dx.doi.org/10.1183/16000617.0114-2020
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