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Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) remains a significant source of mortality in critically ill patients. Characterised by acute, widespread alveolar inflammation and pulmonary oedema, its pathophysiological heterogeneity has meant that targeted treatments have remained elusive. Metabolomic a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488567/ https://www.ncbi.nlm.nih.gov/pubmed/32620587 http://dx.doi.org/10.1183/16000617.0114-2020 |
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author | Robinson, Matthew John Krasnodembskaya, Anna D. |
author_facet | Robinson, Matthew John Krasnodembskaya, Anna D. |
author_sort | Robinson, Matthew John |
collection | PubMed |
description | Acute respiratory distress syndrome (ARDS) remains a significant source of mortality in critically ill patients. Characterised by acute, widespread alveolar inflammation and pulmonary oedema, its pathophysiological heterogeneity has meant that targeted treatments have remained elusive. Metabolomic analysis has made initial steps in characterising the underlying metabolic derangements of ARDS as an indicator of phenotypical class and has identified mitochondrial dysfunction as a potential therapeutic target. Mesenchymal stem cells and their derived extracellular vesicles have shown significant promise as potential therapies in delivering mitochondria in order to redivert metabolism onto physiological pathways. |
format | Online Article Text |
id | pubmed-9488567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94885672022-11-14 Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome Robinson, Matthew John Krasnodembskaya, Anna D. Eur Respir Rev Lung Science Conference Acute respiratory distress syndrome (ARDS) remains a significant source of mortality in critically ill patients. Characterised by acute, widespread alveolar inflammation and pulmonary oedema, its pathophysiological heterogeneity has meant that targeted treatments have remained elusive. Metabolomic analysis has made initial steps in characterising the underlying metabolic derangements of ARDS as an indicator of phenotypical class and has identified mitochondrial dysfunction as a potential therapeutic target. Mesenchymal stem cells and their derived extracellular vesicles have shown significant promise as potential therapies in delivering mitochondria in order to redivert metabolism onto physiological pathways. European Respiratory Society 2020-07-03 /pmc/articles/PMC9488567/ /pubmed/32620587 http://dx.doi.org/10.1183/16000617.0114-2020 Text en Copyright ©ERS 2020. https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Lung Science Conference Robinson, Matthew John Krasnodembskaya, Anna D. Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome |
title | Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome |
title_full | Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome |
title_fullStr | Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome |
title_full_unstemmed | Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome |
title_short | Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome |
title_sort | therapeutic targeting of metabolic alterations in acute respiratory distress syndrome |
topic | Lung Science Conference |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488567/ https://www.ncbi.nlm.nih.gov/pubmed/32620587 http://dx.doi.org/10.1183/16000617.0114-2020 |
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