Cystic fibrosis-related diabetes and lung disease: an update

The development of cystic fibrosis-related diabetes (CFRD) often leads to poorer outcomes in patients with cystic fibrosis including increases in pulmonary exacerbations, poorer lung function and early mortality. This review highlights the many factors contributing to the clinical decline seen in pa...

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Autores principales: Prentice, Bernadette J., Jaffe, Adam, Hameed, Shihab, Verge, Charles F., Waters, Shafagh, Widger, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488640/
https://www.ncbi.nlm.nih.gov/pubmed/33597125
http://dx.doi.org/10.1183/16000617.0293-2020
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author Prentice, Bernadette J.
Jaffe, Adam
Hameed, Shihab
Verge, Charles F.
Waters, Shafagh
Widger, John
author_facet Prentice, Bernadette J.
Jaffe, Adam
Hameed, Shihab
Verge, Charles F.
Waters, Shafagh
Widger, John
author_sort Prentice, Bernadette J.
collection PubMed
description The development of cystic fibrosis-related diabetes (CFRD) often leads to poorer outcomes in patients with cystic fibrosis including increases in pulmonary exacerbations, poorer lung function and early mortality. This review highlights the many factors contributing to the clinical decline seen in patients diagnosed with CFRD, highlighting the important role of nutrition, the direct effect of hyperglycaemia on the lungs, the immunomodulatory effects of high glucose levels and the potential role of genetic modifiers in CFRD.
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spelling pubmed-94886402022-11-14 Cystic fibrosis-related diabetes and lung disease: an update Prentice, Bernadette J. Jaffe, Adam Hameed, Shihab Verge, Charles F. Waters, Shafagh Widger, John Eur Respir Rev Reviews The development of cystic fibrosis-related diabetes (CFRD) often leads to poorer outcomes in patients with cystic fibrosis including increases in pulmonary exacerbations, poorer lung function and early mortality. This review highlights the many factors contributing to the clinical decline seen in patients diagnosed with CFRD, highlighting the important role of nutrition, the direct effect of hyperglycaemia on the lungs, the immunomodulatory effects of high glucose levels and the potential role of genetic modifiers in CFRD. European Respiratory Society 2021-02-17 /pmc/articles/PMC9488640/ /pubmed/33597125 http://dx.doi.org/10.1183/16000617.0293-2020 Text en Copyright ©ERS 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Reviews
Prentice, Bernadette J.
Jaffe, Adam
Hameed, Shihab
Verge, Charles F.
Waters, Shafagh
Widger, John
Cystic fibrosis-related diabetes and lung disease: an update
title Cystic fibrosis-related diabetes and lung disease: an update
title_full Cystic fibrosis-related diabetes and lung disease: an update
title_fullStr Cystic fibrosis-related diabetes and lung disease: an update
title_full_unstemmed Cystic fibrosis-related diabetes and lung disease: an update
title_short Cystic fibrosis-related diabetes and lung disease: an update
title_sort cystic fibrosis-related diabetes and lung disease: an update
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488640/
https://www.ncbi.nlm.nih.gov/pubmed/33597125
http://dx.doi.org/10.1183/16000617.0293-2020
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