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Endoplasmic reticulum stress in lung disease
Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the developme...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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European Respiratory Society
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488656/ https://www.ncbi.nlm.nih.gov/pubmed/28659504 http://dx.doi.org/10.1183/16000617.0018-2017 |
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author | Marciniak, Stefan J. |
author_facet | Marciniak, Stefan J. |
author_sort | Marciniak, Stefan J. |
collection | PubMed |
description | Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease. |
format | Online Article Text |
id | pubmed-9488656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94886562022-11-14 Endoplasmic reticulum stress in lung disease Marciniak, Stefan J. Eur Respir Rev Lung Science Conference Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease. European Respiratory Society 2017-06-28 /pmc/articles/PMC9488656/ /pubmed/28659504 http://dx.doi.org/10.1183/16000617.0018-2017 Text en Copyright ©ERS 2017. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Lung Science Conference Marciniak, Stefan J. Endoplasmic reticulum stress in lung disease |
title | Endoplasmic reticulum stress in lung disease |
title_full | Endoplasmic reticulum stress in lung disease |
title_fullStr | Endoplasmic reticulum stress in lung disease |
title_full_unstemmed | Endoplasmic reticulum stress in lung disease |
title_short | Endoplasmic reticulum stress in lung disease |
title_sort | endoplasmic reticulum stress in lung disease |
topic | Lung Science Conference |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488656/ https://www.ncbi.nlm.nih.gov/pubmed/28659504 http://dx.doi.org/10.1183/16000617.0018-2017 |
work_keys_str_mv | AT marciniakstefanj endoplasmicreticulumstressinlungdisease |