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Endoplasmic reticulum stress in lung disease

Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the developme...

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Autor principal: Marciniak, Stefan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488656/
https://www.ncbi.nlm.nih.gov/pubmed/28659504
http://dx.doi.org/10.1183/16000617.0018-2017
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author Marciniak, Stefan J.
author_facet Marciniak, Stefan J.
author_sort Marciniak, Stefan J.
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description Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease.
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spelling pubmed-94886562022-11-14 Endoplasmic reticulum stress in lung disease Marciniak, Stefan J. Eur Respir Rev Lung Science Conference Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease. European Respiratory Society 2017-06-28 /pmc/articles/PMC9488656/ /pubmed/28659504 http://dx.doi.org/10.1183/16000617.0018-2017 Text en Copyright ©ERS 2017. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Lung Science Conference
Marciniak, Stefan J.
Endoplasmic reticulum stress in lung disease
title Endoplasmic reticulum stress in lung disease
title_full Endoplasmic reticulum stress in lung disease
title_fullStr Endoplasmic reticulum stress in lung disease
title_full_unstemmed Endoplasmic reticulum stress in lung disease
title_short Endoplasmic reticulum stress in lung disease
title_sort endoplasmic reticulum stress in lung disease
topic Lung Science Conference
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488656/
https://www.ncbi.nlm.nih.gov/pubmed/28659504
http://dx.doi.org/10.1183/16000617.0018-2017
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