Identification of a signature of evolutionarily conserved stress-induced mutagenesis in cancer

The clustering of mutations observed in cancer cells is reminiscent of the stress-induced mutagenesis (SIM) response in bacteria. Bacteria deploy SIM when faced with DNA double-strand breaks in the presence of conditions that elicit an SOS response. SIM employs DinB, the evolutionary precursor to hu...

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Detalles Bibliográficos
Autores principales: Cisneros, Luis H., Vaske, Charles, Bussey, Kimberly J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488704/
https://www.ncbi.nlm.nih.gov/pubmed/36147501
http://dx.doi.org/10.3389/fgene.2022.932763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488704/
https://www.ncbi.nlm.nih.gov/pubmed/36147501
http://dx.doi.org/10.3389/fgene.2022.932763

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