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Perspectives for systems biology in the management of tuberculosis
Standardised management of tuberculosis may soon be replaced by individualised, precision medicine-guided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biolo...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488731/ https://www.ncbi.nlm.nih.gov/pubmed/34039674 http://dx.doi.org/10.1183/16000617.0377-2020 |
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author | Kontsevaya, Irina Lange, Christoph Comella-del-Barrio, Patricia Coarfa, Cristian DiNardo, Andrew R. Gillespie, Stephen H. Hauptmann, Matthias Leschczyk, Christoph Mandalakas, Anna M. Martinecz, Antal Merker, Matthias Niemann, Stefan Reimann, Maja Rzhepishevska, Olena Schaible, Ulrich E. Scheu, Katrin M. Schurr, Erwin Abel zur Wiesch, Pia Heyckendorf, Jan |
author_facet | Kontsevaya, Irina Lange, Christoph Comella-del-Barrio, Patricia Coarfa, Cristian DiNardo, Andrew R. Gillespie, Stephen H. Hauptmann, Matthias Leschczyk, Christoph Mandalakas, Anna M. Martinecz, Antal Merker, Matthias Niemann, Stefan Reimann, Maja Rzhepishevska, Olena Schaible, Ulrich E. Scheu, Katrin M. Schurr, Erwin Abel zur Wiesch, Pia Heyckendorf, Jan |
author_sort | Kontsevaya, Irina |
collection | PubMed |
description | Standardised management of tuberculosis may soon be replaced by individualised, precision medicine-guided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biological systems that can provide insights into mechanisms underlying tuberculosis, identify novel biomarkers, and help to optimise prevention, diagnosis and treatment of disease. These advances are critically important in the context of the evolving epidemic of drug-resistant tuberculosis. Here, we review the available evidence on the role of systems biology approaches – human and mycobacterial genomics and transcriptomics, proteomics, lipidomics/metabolomics, immunophenotyping, systems pharmacology and gut microbiomes – in the management of tuberculosis including prediction of risk for disease progression, severity of mycobacterial virulence and drug resistance, adverse events, comorbidities, response to therapy and treatment outcomes. Application of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach demonstrated that at present most of the studies provide “very low” certainty of evidence for answering clinically relevant questions. Further studies in large prospective cohorts of patients, including randomised clinical trials, are necessary to assess the applicability of the findings in tuberculosis prevention and more efficient clinical management of patients. |
format | Online Article Text |
id | pubmed-9488731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94887312022-11-14 Perspectives for systems biology in the management of tuberculosis Kontsevaya, Irina Lange, Christoph Comella-del-Barrio, Patricia Coarfa, Cristian DiNardo, Andrew R. Gillespie, Stephen H. Hauptmann, Matthias Leschczyk, Christoph Mandalakas, Anna M. Martinecz, Antal Merker, Matthias Niemann, Stefan Reimann, Maja Rzhepishevska, Olena Schaible, Ulrich E. Scheu, Katrin M. Schurr, Erwin Abel zur Wiesch, Pia Heyckendorf, Jan Eur Respir Rev Reviews Standardised management of tuberculosis may soon be replaced by individualised, precision medicine-guided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biological systems that can provide insights into mechanisms underlying tuberculosis, identify novel biomarkers, and help to optimise prevention, diagnosis and treatment of disease. These advances are critically important in the context of the evolving epidemic of drug-resistant tuberculosis. Here, we review the available evidence on the role of systems biology approaches – human and mycobacterial genomics and transcriptomics, proteomics, lipidomics/metabolomics, immunophenotyping, systems pharmacology and gut microbiomes – in the management of tuberculosis including prediction of risk for disease progression, severity of mycobacterial virulence and drug resistance, adverse events, comorbidities, response to therapy and treatment outcomes. Application of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach demonstrated that at present most of the studies provide “very low” certainty of evidence for answering clinically relevant questions. Further studies in large prospective cohorts of patients, including randomised clinical trials, are necessary to assess the applicability of the findings in tuberculosis prevention and more efficient clinical management of patients. European Respiratory Society 2021-05-26 /pmc/articles/PMC9488731/ /pubmed/34039674 http://dx.doi.org/10.1183/16000617.0377-2020 Text en Copyright ©The authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Reviews Kontsevaya, Irina Lange, Christoph Comella-del-Barrio, Patricia Coarfa, Cristian DiNardo, Andrew R. Gillespie, Stephen H. Hauptmann, Matthias Leschczyk, Christoph Mandalakas, Anna M. Martinecz, Antal Merker, Matthias Niemann, Stefan Reimann, Maja Rzhepishevska, Olena Schaible, Ulrich E. Scheu, Katrin M. Schurr, Erwin Abel zur Wiesch, Pia Heyckendorf, Jan Perspectives for systems biology in the management of tuberculosis |
title | Perspectives for systems biology in the management of tuberculosis |
title_full | Perspectives for systems biology in the management of tuberculosis |
title_fullStr | Perspectives for systems biology in the management of tuberculosis |
title_full_unstemmed | Perspectives for systems biology in the management of tuberculosis |
title_short | Perspectives for systems biology in the management of tuberculosis |
title_sort | perspectives for systems biology in the management of tuberculosis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488731/ https://www.ncbi.nlm.nih.gov/pubmed/34039674 http://dx.doi.org/10.1183/16000617.0377-2020 |
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