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The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease

Matrikines are bioactive fragments of the extracellular matrix (ECM) that are fundamental in regulating a diverse array of physiological processes. The tripeptide Proline-Glycine-Proline (PGP) is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. In thi...

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Autores principales: Patel, Dhiren F., Snelgrove, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488800/
https://www.ncbi.nlm.nih.gov/pubmed/29950303
http://dx.doi.org/10.1183/16000617.0017-2018
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author Patel, Dhiren F.
Snelgrove, Robert J.
author_facet Patel, Dhiren F.
Snelgrove, Robert J.
author_sort Patel, Dhiren F.
collection PubMed
description Matrikines are bioactive fragments of the extracellular matrix (ECM) that are fundamental in regulating a diverse array of physiological processes. The tripeptide Proline-Glycine-Proline (PGP) is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. In this article, we describe our current understanding of the pathways that generate, degrade and modify PGP to dictate its bioavailability and stability. Additionally, we discuss our expanding appreciation of the capacity of PGP to regulate diverse cell types and biological processes, independent of its activity on neutrophils, including a putative role in wound repair. We argue that PGP functions as a primitive and conserved damage-associated molecular pattern, which is generated during infection or injury and subsequently acts to shape ensuing inflammatory and repair processes. As a fragment of the ECM that accumulates at the epicentre of the action, PGP is perfectly positioned to focus neutrophils to the exact site required and direct a localised repair response. However, it is essential that PGP is efficiently degraded, as if this matrikine is allowed to persist then pathology can ensue. Accordingly, we discuss how this pathway is subverted in chronic lung diseases giving rise to persistent inflammation and pathological tissue remodelling.
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spelling pubmed-94888002022-11-14 The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease Patel, Dhiren F. Snelgrove, Robert J. Eur Respir Rev Lung Science Conference Matrikines are bioactive fragments of the extracellular matrix (ECM) that are fundamental in regulating a diverse array of physiological processes. The tripeptide Proline-Glycine-Proline (PGP) is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. In this article, we describe our current understanding of the pathways that generate, degrade and modify PGP to dictate its bioavailability and stability. Additionally, we discuss our expanding appreciation of the capacity of PGP to regulate diverse cell types and biological processes, independent of its activity on neutrophils, including a putative role in wound repair. We argue that PGP functions as a primitive and conserved damage-associated molecular pattern, which is generated during infection or injury and subsequently acts to shape ensuing inflammatory and repair processes. As a fragment of the ECM that accumulates at the epicentre of the action, PGP is perfectly positioned to focus neutrophils to the exact site required and direct a localised repair response. However, it is essential that PGP is efficiently degraded, as if this matrikine is allowed to persist then pathology can ensue. Accordingly, we discuss how this pathway is subverted in chronic lung diseases giving rise to persistent inflammation and pathological tissue remodelling. European Respiratory Society 2018-06-27 /pmc/articles/PMC9488800/ /pubmed/29950303 http://dx.doi.org/10.1183/16000617.0017-2018 Text en Copyright ©ERS 2018. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Lung Science Conference
Patel, Dhiren F.
Snelgrove, Robert J.
The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
title The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
title_full The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
title_fullStr The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
title_full_unstemmed The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
title_short The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
title_sort multifaceted roles of the matrikine pro-gly-pro in pulmonary health and disease
topic Lung Science Conference
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488800/
https://www.ncbi.nlm.nih.gov/pubmed/29950303
http://dx.doi.org/10.1183/16000617.0017-2018
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