Management of Mycobacterium avium complex and Mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments

Nontuberculous mycobacterial pulmonary disease (NTM-PD) remains a challenging condition to diagnose and treat effectively. Treatment of NTM-PD is prolonged, frequently associated with adverse effects and has variable success. In this review, we consider the factors influencing clinicians when treati...

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Autores principales: Kumar, Kartik, Daley, Charles L., Griffith, David E., Loebinger, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488909/
https://www.ncbi.nlm.nih.gov/pubmed/35140106
http://dx.doi.org/10.1183/16000617.0212-2021
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author Kumar, Kartik
Daley, Charles L.
Griffith, David E.
Loebinger, Michael R.
author_facet Kumar, Kartik
Daley, Charles L.
Griffith, David E.
Loebinger, Michael R.
author_sort Kumar, Kartik
collection PubMed
description Nontuberculous mycobacterial pulmonary disease (NTM-PD) remains a challenging condition to diagnose and treat effectively. Treatment of NTM-PD is prolonged, frequently associated with adverse effects and has variable success. In this review, we consider the factors influencing clinicians when treating NTM-PD and discuss outcomes from key studies on the pharmacological management of Mycobacterium avium complex pulmonary disease and M. abscessus pulmonary disease. We highlight issues relating to treatment-related toxicity and provide an overview of repurposed and emerging therapies for NTM-PD.
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spelling pubmed-94889092022-11-14 Management of Mycobacterium avium complex and Mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments Kumar, Kartik Daley, Charles L. Griffith, David E. Loebinger, Michael R. Eur Respir Rev Reviews Nontuberculous mycobacterial pulmonary disease (NTM-PD) remains a challenging condition to diagnose and treat effectively. Treatment of NTM-PD is prolonged, frequently associated with adverse effects and has variable success. In this review, we consider the factors influencing clinicians when treating NTM-PD and discuss outcomes from key studies on the pharmacological management of Mycobacterium avium complex pulmonary disease and M. abscessus pulmonary disease. We highlight issues relating to treatment-related toxicity and provide an overview of repurposed and emerging therapies for NTM-PD. European Respiratory Society 2022-02-09 /pmc/articles/PMC9488909/ /pubmed/35140106 http://dx.doi.org/10.1183/16000617.0212-2021 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Reviews
Kumar, Kartik
Daley, Charles L.
Griffith, David E.
Loebinger, Michael R.
Management of Mycobacterium avium complex and Mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments
title Management of Mycobacterium avium complex and Mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments
title_full Management of Mycobacterium avium complex and Mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments
title_fullStr Management of Mycobacterium avium complex and Mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments
title_full_unstemmed Management of Mycobacterium avium complex and Mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments
title_short Management of Mycobacterium avium complex and Mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments
title_sort management of mycobacterium avium complex and mycobacterium abscessus pulmonary disease: therapeutic advances and emerging treatments
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488909/
https://www.ncbi.nlm.nih.gov/pubmed/35140106
http://dx.doi.org/10.1183/16000617.0212-2021
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