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The genetics of interstitial lung diseases

Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if pr...

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Autores principales: Borie, Raphael, Le Guen, Pierre, Ghanem, Mada, Taillé, Camille, Dupin, Clairelyne, Dieudé, Philippe, Kannengiesser, Caroline, Crestani, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488931/
https://www.ncbi.nlm.nih.gov/pubmed/31554702
http://dx.doi.org/10.1183/16000617.0053-2019
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author Borie, Raphael
Le Guen, Pierre
Ghanem, Mada
Taillé, Camille
Dupin, Clairelyne
Dieudé, Philippe
Kannengiesser, Caroline
Crestani, Bruno
author_facet Borie, Raphael
Le Guen, Pierre
Ghanem, Mada
Taillé, Camille
Dupin, Clairelyne
Dieudé, Philippe
Kannengiesser, Caroline
Crestani, Bruno
author_sort Borie, Raphael
collection PubMed
description Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD.
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spelling pubmed-94889312022-11-14 The genetics of interstitial lung diseases Borie, Raphael Le Guen, Pierre Ghanem, Mada Taillé, Camille Dupin, Clairelyne Dieudé, Philippe Kannengiesser, Caroline Crestani, Bruno Eur Respir Rev Review Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD. European Respiratory Society 2019-09-25 /pmc/articles/PMC9488931/ /pubmed/31554702 http://dx.doi.org/10.1183/16000617.0053-2019 Text en Copyright ©ERS 2019. https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Review
Borie, Raphael
Le Guen, Pierre
Ghanem, Mada
Taillé, Camille
Dupin, Clairelyne
Dieudé, Philippe
Kannengiesser, Caroline
Crestani, Bruno
The genetics of interstitial lung diseases
title The genetics of interstitial lung diseases
title_full The genetics of interstitial lung diseases
title_fullStr The genetics of interstitial lung diseases
title_full_unstemmed The genetics of interstitial lung diseases
title_short The genetics of interstitial lung diseases
title_sort genetics of interstitial lung diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488931/
https://www.ncbi.nlm.nih.gov/pubmed/31554702
http://dx.doi.org/10.1183/16000617.0053-2019
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