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The genetics of interstitial lung diseases
Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if pr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488931/ https://www.ncbi.nlm.nih.gov/pubmed/31554702 http://dx.doi.org/10.1183/16000617.0053-2019 |
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author | Borie, Raphael Le Guen, Pierre Ghanem, Mada Taillé, Camille Dupin, Clairelyne Dieudé, Philippe Kannengiesser, Caroline Crestani, Bruno |
author_facet | Borie, Raphael Le Guen, Pierre Ghanem, Mada Taillé, Camille Dupin, Clairelyne Dieudé, Philippe Kannengiesser, Caroline Crestani, Bruno |
author_sort | Borie, Raphael |
collection | PubMed |
description | Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD. |
format | Online Article Text |
id | pubmed-9488931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94889312022-11-14 The genetics of interstitial lung diseases Borie, Raphael Le Guen, Pierre Ghanem, Mada Taillé, Camille Dupin, Clairelyne Dieudé, Philippe Kannengiesser, Caroline Crestani, Bruno Eur Respir Rev Review Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD. European Respiratory Society 2019-09-25 /pmc/articles/PMC9488931/ /pubmed/31554702 http://dx.doi.org/10.1183/16000617.0053-2019 Text en Copyright ©ERS 2019. https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Review Borie, Raphael Le Guen, Pierre Ghanem, Mada Taillé, Camille Dupin, Clairelyne Dieudé, Philippe Kannengiesser, Caroline Crestani, Bruno The genetics of interstitial lung diseases |
title | The genetics of interstitial lung diseases |
title_full | The genetics of interstitial lung diseases |
title_fullStr | The genetics of interstitial lung diseases |
title_full_unstemmed | The genetics of interstitial lung diseases |
title_short | The genetics of interstitial lung diseases |
title_sort | genetics of interstitial lung diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488931/ https://www.ncbi.nlm.nih.gov/pubmed/31554702 http://dx.doi.org/10.1183/16000617.0053-2019 |
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