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Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature

Carcinoid tumours are rare neuroendocrine neoplasms that mostly occur in younger adults with low tendencies to metastasise. Based on their histological characteristics, they are divided into typical and atypical subtypes. The most common presenting symptoms are due to central airway obstruction. The...

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Autores principales: Papaporfyriou, Anastasia, Domayer, Julian, Meilinger, Michael, Firlinger, Irene, Funk, Georg-Christian, Setinek, Ulrike, Kostikas, Konstantinos, Valipour, Arschang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488937/
https://www.ncbi.nlm.nih.gov/pubmed/33408086
http://dx.doi.org/10.1183/16000617.0115-2020
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author Papaporfyriou, Anastasia
Domayer, Julian
Meilinger, Michael
Firlinger, Irene
Funk, Georg-Christian
Setinek, Ulrike
Kostikas, Konstantinos
Valipour, Arschang
author_facet Papaporfyriou, Anastasia
Domayer, Julian
Meilinger, Michael
Firlinger, Irene
Funk, Georg-Christian
Setinek, Ulrike
Kostikas, Konstantinos
Valipour, Arschang
author_sort Papaporfyriou, Anastasia
collection PubMed
description Carcinoid tumours are rare neuroendocrine neoplasms that mostly occur in younger adults with low tendencies to metastasise. Based on their histological characteristics, they are divided into typical and atypical subtypes. The most common presenting symptoms are due to central airway obstruction. The first step in the diagnostic assessment should be a computed tomography (CT) scan, as it provides information both for local tumour extent and lymph node involvement. Bronchoscopy is the main tool for histological confirmation, evaluation of bronchial wall invasion and removal of endobronchial manifestation with subsequent resolution of atelectasis. Endobronchial ultrasound may be necessary to rule out lymph node metastasis. Somatostatin receptor scintigraphy in combination with CT can rule out further metastatic disease. Surgical resection using parenchyma-sparing techniques remains the gold standard for treatment. For selected patients, endobronchial therapy could be an alternative for minimal invasiveness. Long-term follow-up is suggested due to the high likelihood of recurrence. Here, we describe our clinical experience in a 35-year-old male patient who originally presented with haemoptysis and a central polypoid tumour in the left main bronchus revealed by a CT scan. The histological characteristics were indicative of a typical carcinoid. The patient was treated using an endobronchial approach only. No complications and no recurrences have been observed in a follow-up of 2 years.
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spelling pubmed-94889372022-11-14 Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature Papaporfyriou, Anastasia Domayer, Julian Meilinger, Michael Firlinger, Irene Funk, Georg-Christian Setinek, Ulrike Kostikas, Konstantinos Valipour, Arschang Eur Respir Rev Reviews Carcinoid tumours are rare neuroendocrine neoplasms that mostly occur in younger adults with low tendencies to metastasise. Based on their histological characteristics, they are divided into typical and atypical subtypes. The most common presenting symptoms are due to central airway obstruction. The first step in the diagnostic assessment should be a computed tomography (CT) scan, as it provides information both for local tumour extent and lymph node involvement. Bronchoscopy is the main tool for histological confirmation, evaluation of bronchial wall invasion and removal of endobronchial manifestation with subsequent resolution of atelectasis. Endobronchial ultrasound may be necessary to rule out lymph node metastasis. Somatostatin receptor scintigraphy in combination with CT can rule out further metastatic disease. Surgical resection using parenchyma-sparing techniques remains the gold standard for treatment. For selected patients, endobronchial therapy could be an alternative for minimal invasiveness. Long-term follow-up is suggested due to the high likelihood of recurrence. Here, we describe our clinical experience in a 35-year-old male patient who originally presented with haemoptysis and a central polypoid tumour in the left main bronchus revealed by a CT scan. The histological characteristics were indicative of a typical carcinoid. The patient was treated using an endobronchial approach only. No complications and no recurrences have been observed in a follow-up of 2 years. European Respiratory Society 2021-01-06 /pmc/articles/PMC9488937/ /pubmed/33408086 http://dx.doi.org/10.1183/16000617.0115-2020 Text en Copyright ©ERS 2021. https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Reviews
Papaporfyriou, Anastasia
Domayer, Julian
Meilinger, Michael
Firlinger, Irene
Funk, Georg-Christian
Setinek, Ulrike
Kostikas, Konstantinos
Valipour, Arschang
Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature
title Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature
title_full Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature
title_fullStr Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature
title_full_unstemmed Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature
title_short Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature
title_sort bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488937/
https://www.ncbi.nlm.nih.gov/pubmed/33408086
http://dx.doi.org/10.1183/16000617.0115-2020
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