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Systematic review and meta-analysis of residential radon and lung cancer in never-smokers

BACKGROUND: Globally, radon is the leading risk factor for lung cancer in never-smokers (LCINS). In this study, we systematically reviewed and meta-analysed the evidence of the risk of LCINS associated with residential radon exposure. METHODS: Medline and Embase databases were searched using predefi...

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Autores principales: Cheng, Elvin S., Egger, Sam, Hughes, Suzanne, Weber, Marianne, Steinberg, Julia, Rahman, Bayzidur, Worth, Heather, Ruano-Ravina, Alberto, Rawstorne, Patrick, Yu, Xue Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488946/
https://www.ncbi.nlm.nih.gov/pubmed/33536262
http://dx.doi.org/10.1183/16000617.0230-2020
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author Cheng, Elvin S.
Egger, Sam
Hughes, Suzanne
Weber, Marianne
Steinberg, Julia
Rahman, Bayzidur
Worth, Heather
Ruano-Ravina, Alberto
Rawstorne, Patrick
Yu, Xue Qin
author_facet Cheng, Elvin S.
Egger, Sam
Hughes, Suzanne
Weber, Marianne
Steinberg, Julia
Rahman, Bayzidur
Worth, Heather
Ruano-Ravina, Alberto
Rawstorne, Patrick
Yu, Xue Qin
author_sort Cheng, Elvin S.
collection PubMed
description BACKGROUND: Globally, radon is the leading risk factor for lung cancer in never-smokers (LCINS). In this study, we systematically reviewed and meta-analysed the evidence of the risk of LCINS associated with residential radon exposure. METHODS: Medline and Embase databases were searched using predefined inclusion and exclusion criteria to identify relevant studies published from 1 January 1990 to 5 March 2020 focused on never-smokers. We identified four pooled collaborative studies (incorporating data from 24 case–control studies), one case–control study and one cohort study for systematic review. Meta-analysis was performed on the results of the four pooled studies due to different measures of effect and outcome reported in the cohort study and insufficient information reported for the case–control study. In a post hoc analysis, the corresponding risk for ever-smokers was also examined. RESULTS: Risk estimates of lung cancer from residential radon exposure were pooled in the meta-analysis for 2341 never-smoker cases, 8967 never-smoker controls, 9937 ever-smoker cases and 12 463 ever-smoker controls. Adjusted excess relative risks (aERRs) per 100 Bq·m(−3) of radon level were 0.15 (95% CI 0.06–0.25) for never-smokers and 0.09 (95% CI 0.03–0.16) for ever-smokers, and the difference between them was statistically insignificant (p=0.32). The aERR per 100 Bq·m(−3)was higher for men (0.46; 95% CI 0.15–0.76) than for women (0.09; 95% CI −0.02–0.20) among never-smokers (p=0.027). CONCLUSION: This study provided quantified risk estimates for lung cancer from residential radon exposure among both never-smokers and ever-smokers. Among never-smokers in radon-prone areas, men were at higher risk of lung cancer than women.
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spelling pubmed-94889462022-11-14 Systematic review and meta-analysis of residential radon and lung cancer in never-smokers Cheng, Elvin S. Egger, Sam Hughes, Suzanne Weber, Marianne Steinberg, Julia Rahman, Bayzidur Worth, Heather Ruano-Ravina, Alberto Rawstorne, Patrick Yu, Xue Qin Eur Respir Rev Reviews BACKGROUND: Globally, radon is the leading risk factor for lung cancer in never-smokers (LCINS). In this study, we systematically reviewed and meta-analysed the evidence of the risk of LCINS associated with residential radon exposure. METHODS: Medline and Embase databases were searched using predefined inclusion and exclusion criteria to identify relevant studies published from 1 January 1990 to 5 March 2020 focused on never-smokers. We identified four pooled collaborative studies (incorporating data from 24 case–control studies), one case–control study and one cohort study for systematic review. Meta-analysis was performed on the results of the four pooled studies due to different measures of effect and outcome reported in the cohort study and insufficient information reported for the case–control study. In a post hoc analysis, the corresponding risk for ever-smokers was also examined. RESULTS: Risk estimates of lung cancer from residential radon exposure were pooled in the meta-analysis for 2341 never-smoker cases, 8967 never-smoker controls, 9937 ever-smoker cases and 12 463 ever-smoker controls. Adjusted excess relative risks (aERRs) per 100 Bq·m(−3) of radon level were 0.15 (95% CI 0.06–0.25) for never-smokers and 0.09 (95% CI 0.03–0.16) for ever-smokers, and the difference between them was statistically insignificant (p=0.32). The aERR per 100 Bq·m(−3)was higher for men (0.46; 95% CI 0.15–0.76) than for women (0.09; 95% CI −0.02–0.20) among never-smokers (p=0.027). CONCLUSION: This study provided quantified risk estimates for lung cancer from residential radon exposure among both never-smokers and ever-smokers. Among never-smokers in radon-prone areas, men were at higher risk of lung cancer than women. European Respiratory Society 2021-02-03 /pmc/articles/PMC9488946/ /pubmed/33536262 http://dx.doi.org/10.1183/16000617.0230-2020 Text en Copyright ©ERS 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Reviews
Cheng, Elvin S.
Egger, Sam
Hughes, Suzanne
Weber, Marianne
Steinberg, Julia
Rahman, Bayzidur
Worth, Heather
Ruano-Ravina, Alberto
Rawstorne, Patrick
Yu, Xue Qin
Systematic review and meta-analysis of residential radon and lung cancer in never-smokers
title Systematic review and meta-analysis of residential radon and lung cancer in never-smokers
title_full Systematic review and meta-analysis of residential radon and lung cancer in never-smokers
title_fullStr Systematic review and meta-analysis of residential radon and lung cancer in never-smokers
title_full_unstemmed Systematic review and meta-analysis of residential radon and lung cancer in never-smokers
title_short Systematic review and meta-analysis of residential radon and lung cancer in never-smokers
title_sort systematic review and meta-analysis of residential radon and lung cancer in never-smokers
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488946/
https://www.ncbi.nlm.nih.gov/pubmed/33536262
http://dx.doi.org/10.1183/16000617.0230-2020
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