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Shared epithelial pathways to lung repair and disease

Chronic lung diseases present tremendous health burdens and share a common pathobiology of dysfunctional epithelial repair. Lung adenocarcinoma, the leading cancer killer worldwide, is caused mainly by chemical carcinogens of tobacco smoke that induce mutations in pulmonary epithelial cells leading...

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Detalles Bibliográficos
Autores principales: Spella, Magda, Lilis, Ioannis, Stathopoulos, Georgios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488986/
https://www.ncbi.nlm.nih.gov/pubmed/28659498
http://dx.doi.org/10.1183/16000617.0048-2017
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author Spella, Magda
Lilis, Ioannis
Stathopoulos, Georgios T.
author_facet Spella, Magda
Lilis, Ioannis
Stathopoulos, Georgios T.
author_sort Spella, Magda
collection PubMed
description Chronic lung diseases present tremendous health burdens and share a common pathobiology of dysfunctional epithelial repair. Lung adenocarcinoma, the leading cancer killer worldwide, is caused mainly by chemical carcinogens of tobacco smoke that induce mutations in pulmonary epithelial cells leading to uncontrolled epithelial proliferation. Lung epithelial cells that possess the capacity for self-renewal and regeneration of other lung cell types are believed to underlie the pathobiology of chronic obstructive, fibrotic and neoplastic lung disorders. However, the understanding of lung epithelial progenitor cell hierarchy and turnover is incomplete and a comprehensive model of the cellular and transcriptional events that underlie lung regeneration and carcinogenesis is missing. The mapping of these processes is extremely important, since their modulation would potentially allow effective cure and/or prevention of chronic lung diseases. In this review we describe current knowledge on cellular and molecular pathways at play during lung repair and carcinogenesis and summarise the critical lung cell populations with regenerative and cancerous potential.
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spelling pubmed-94889862022-11-14 Shared epithelial pathways to lung repair and disease Spella, Magda Lilis, Ioannis Stathopoulos, Georgios T. Eur Respir Rev Lung Science Conference Chronic lung diseases present tremendous health burdens and share a common pathobiology of dysfunctional epithelial repair. Lung adenocarcinoma, the leading cancer killer worldwide, is caused mainly by chemical carcinogens of tobacco smoke that induce mutations in pulmonary epithelial cells leading to uncontrolled epithelial proliferation. Lung epithelial cells that possess the capacity for self-renewal and regeneration of other lung cell types are believed to underlie the pathobiology of chronic obstructive, fibrotic and neoplastic lung disorders. However, the understanding of lung epithelial progenitor cell hierarchy and turnover is incomplete and a comprehensive model of the cellular and transcriptional events that underlie lung regeneration and carcinogenesis is missing. The mapping of these processes is extremely important, since their modulation would potentially allow effective cure and/or prevention of chronic lung diseases. In this review we describe current knowledge on cellular and molecular pathways at play during lung repair and carcinogenesis and summarise the critical lung cell populations with regenerative and cancerous potential. European Respiratory Society 2017-06-28 /pmc/articles/PMC9488986/ /pubmed/28659498 http://dx.doi.org/10.1183/16000617.0048-2017 Text en Copyright ©ERS 2017. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Lung Science Conference
Spella, Magda
Lilis, Ioannis
Stathopoulos, Georgios T.
Shared epithelial pathways to lung repair and disease
title Shared epithelial pathways to lung repair and disease
title_full Shared epithelial pathways to lung repair and disease
title_fullStr Shared epithelial pathways to lung repair and disease
title_full_unstemmed Shared epithelial pathways to lung repair and disease
title_short Shared epithelial pathways to lung repair and disease
title_sort shared epithelial pathways to lung repair and disease
topic Lung Science Conference
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488986/
https://www.ncbi.nlm.nih.gov/pubmed/28659498
http://dx.doi.org/10.1183/16000617.0048-2017
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