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From systems biology to P4 medicine: applications in respiratory medicine

Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diag...

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Detalles Bibliográficos
Autores principales: Noell, Guillaume, Faner, Rosa, Agustí, Alvar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489012/
https://www.ncbi.nlm.nih.gov/pubmed/29436404
http://dx.doi.org/10.1183/16000617.0110-2017
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author Noell, Guillaume
Faner, Rosa
Agustí, Alvar
author_facet Noell, Guillaume
Faner, Rosa
Agustí, Alvar
author_sort Noell, Guillaume
collection PubMed
description Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, “omics” data and bioinformatic computing power. It paves the way forward towards “P4 medicine” (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases. In this review, we: 1) discuss the principles of systems biology; 2) elaborate on how P4 medicine has the potential to shift healthcare from reactive medicine (treatment of illness) to predict and prevent illness, in a revolution that will be personalised in nature, probabilistic in essence and participatory driven; 3) review the current state of the art of network (systems) medicine in three prevalent respiratory diseases (chronic obstructive pulmonary disease, asthma and lung cancer); and 4) outline current challenges and future goals in the field.
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spelling pubmed-94890122022-11-14 From systems biology to P4 medicine: applications in respiratory medicine Noell, Guillaume Faner, Rosa Agustí, Alvar Eur Respir Rev Series Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, “omics” data and bioinformatic computing power. It paves the way forward towards “P4 medicine” (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases. In this review, we: 1) discuss the principles of systems biology; 2) elaborate on how P4 medicine has the potential to shift healthcare from reactive medicine (treatment of illness) to predict and prevent illness, in a revolution that will be personalised in nature, probabilistic in essence and participatory driven; 3) review the current state of the art of network (systems) medicine in three prevalent respiratory diseases (chronic obstructive pulmonary disease, asthma and lung cancer); and 4) outline current challenges and future goals in the field. European Respiratory Society 2018-02-07 /pmc/articles/PMC9489012/ /pubmed/29436404 http://dx.doi.org/10.1183/16000617.0110-2017 Text en Copyright ©ERS 2018. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Series
Noell, Guillaume
Faner, Rosa
Agustí, Alvar
From systems biology to P4 medicine: applications in respiratory medicine
title From systems biology to P4 medicine: applications in respiratory medicine
title_full From systems biology to P4 medicine: applications in respiratory medicine
title_fullStr From systems biology to P4 medicine: applications in respiratory medicine
title_full_unstemmed From systems biology to P4 medicine: applications in respiratory medicine
title_short From systems biology to P4 medicine: applications in respiratory medicine
title_sort from systems biology to p4 medicine: applications in respiratory medicine
topic Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489012/
https://www.ncbi.nlm.nih.gov/pubmed/29436404
http://dx.doi.org/10.1183/16000617.0110-2017
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