Cargando…
Cardiopulmonary exercise testing in interstitial lung diseases and the value of ventilatory efficiency
Interstitial lung diseases (ILDs) are diverse parenchymal pulmonary disorders, primarily characterised by alveolar and interstitial inflammation and/or fibrosis, and sharing pathophysiological similarities. Thus, patients generally harbour common respiratory symptoms, lung function abnormalities and...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489146/ https://www.ncbi.nlm.nih.gov/pubmed/34853093 http://dx.doi.org/10.1183/16000617.0355-2020 |
_version_ | 1784792814101463040 |
---|---|
author | Gille, Thomas Laveneziana, Pierantonio |
author_facet | Gille, Thomas Laveneziana, Pierantonio |
author_sort | Gille, Thomas |
collection | PubMed |
description | Interstitial lung diseases (ILDs) are diverse parenchymal pulmonary disorders, primarily characterised by alveolar and interstitial inflammation and/or fibrosis, and sharing pathophysiological similarities. Thus, patients generally harbour common respiratory symptoms, lung function abnormalities and modified exercise adaptation. The most usual and disabling complaint is exertional dyspnoea, frequently responsible for premature exercise interruption. Cardiopulmonary exercise testing (CPET) is increasingly used for the clinical assessment of patients with ILD. This is because exercise performance or dyspnoea on exertion cannot reliably be predicted by resting pulmonary function tests. CPET, therefore, provides an accurate evaluation of functional capacity on an individual basis. CPET can unmask anomalies in the integrated functions of the respiratory, cardiovascular, metabolic, peripheral muscle and neurosensory systems in ILDs. CPET uniquely provides an evaluation of all above aspects and can help clinicians shape ILD patient management. Preliminary evidence suggests that CPET may also generate valuable prognostic information in ILDs and can be used to shed light on the presence of associated pulmonary hypertension. This review aims to provide comprehensive and updated evidence concerning the clinical utility of CPET in ILD patients, with particular focus on the physiological and clinical value of ventilatory efficiency (V˙(E)/V˙(CO(2))). |
format | Online Article Text |
id | pubmed-9489146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94891462022-11-14 Cardiopulmonary exercise testing in interstitial lung diseases and the value of ventilatory efficiency Gille, Thomas Laveneziana, Pierantonio Eur Respir Rev Series Interstitial lung diseases (ILDs) are diverse parenchymal pulmonary disorders, primarily characterised by alveolar and interstitial inflammation and/or fibrosis, and sharing pathophysiological similarities. Thus, patients generally harbour common respiratory symptoms, lung function abnormalities and modified exercise adaptation. The most usual and disabling complaint is exertional dyspnoea, frequently responsible for premature exercise interruption. Cardiopulmonary exercise testing (CPET) is increasingly used for the clinical assessment of patients with ILD. This is because exercise performance or dyspnoea on exertion cannot reliably be predicted by resting pulmonary function tests. CPET, therefore, provides an accurate evaluation of functional capacity on an individual basis. CPET can unmask anomalies in the integrated functions of the respiratory, cardiovascular, metabolic, peripheral muscle and neurosensory systems in ILDs. CPET uniquely provides an evaluation of all above aspects and can help clinicians shape ILD patient management. Preliminary evidence suggests that CPET may also generate valuable prognostic information in ILDs and can be used to shed light on the presence of associated pulmonary hypertension. This review aims to provide comprehensive and updated evidence concerning the clinical utility of CPET in ILD patients, with particular focus on the physiological and clinical value of ventilatory efficiency (V˙(E)/V˙(CO(2))). European Respiratory Society 2021-12-01 /pmc/articles/PMC9489146/ /pubmed/34853093 http://dx.doi.org/10.1183/16000617.0355-2020 Text en Copyright ©The authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Series Gille, Thomas Laveneziana, Pierantonio Cardiopulmonary exercise testing in interstitial lung diseases and the value of ventilatory efficiency |
title | Cardiopulmonary exercise testing in interstitial lung diseases and the value of ventilatory efficiency |
title_full | Cardiopulmonary exercise testing in interstitial lung diseases and the value of ventilatory efficiency |
title_fullStr | Cardiopulmonary exercise testing in interstitial lung diseases and the value of ventilatory efficiency |
title_full_unstemmed | Cardiopulmonary exercise testing in interstitial lung diseases and the value of ventilatory efficiency |
title_short | Cardiopulmonary exercise testing in interstitial lung diseases and the value of ventilatory efficiency |
title_sort | cardiopulmonary exercise testing in interstitial lung diseases and the value of ventilatory efficiency |
topic | Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489146/ https://www.ncbi.nlm.nih.gov/pubmed/34853093 http://dx.doi.org/10.1183/16000617.0355-2020 |
work_keys_str_mv | AT gillethomas cardiopulmonaryexercisetestingininterstitiallungdiseasesandthevalueofventilatoryefficiency AT lavenezianapierantonio cardiopulmonaryexercisetestingininterstitiallungdiseasesandthevalueofventilatoryefficiency |