IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans

Serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein are surrogate markers of immune response. We evaluated antibody levels pre and post third vaccine (booster) and compared responses among different cancer-bearing and normal veterans. Both total and neutral...

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Detalles Bibliográficos
Autores principales: Frankel, Arthur, Capozzola, Tazio, Andrabi, Raiees, Ahn, Chul, Burton, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Indolent B-Cell Lymphoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489243/
http://dx.doi.org/10.1016/S2152-2650(22)01548-8
Descripción
Sumario:Serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein are surrogate markers of immune response. We evaluated antibody levels pre and post third vaccine (booster) and compared responses among different cancer-bearing and normal veterans. Both total and neutralizing antibody levels increased in most subjects after the booster, but the frequency and magnitude of responses were lower in patients with B-cell malignancies undergoing therapy. Neutralizing antibody responses to omicron variants were reduced relative to wild-type and other variants. Additional prevention and prophylactic measures are warranted for poor vaccine responders.

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