IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans

Serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein are surrogate markers of immune response. We evaluated antibody levels pre and post third vaccine (booster) and compared responses among different cancer-bearing and normal veterans. Both total and neutral...

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Autores principales: Frankel, Arthur, Capozzola, Tazio, Andrabi, Raiees, Ahn, Chul, Burton, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Indolent B-Cell Lymphoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489243/
http://dx.doi.org/10.1016/S2152-2650(22)01548-8
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author Frankel, Arthur
Capozzola, Tazio
Andrabi, Raiees
Ahn, Chul
Burton, Dennis
author_facet Frankel, Arthur
Capozzola, Tazio
Andrabi, Raiees
Ahn, Chul
Burton, Dennis
author_sort Frankel, Arthur
collection PubMed
description Serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein are surrogate markers of immune response. We evaluated antibody levels pre and post third vaccine (booster) and compared responses among different cancer-bearing and normal veterans. Both total and neutralizing antibody levels increased in most subjects after the booster, but the frequency and magnitude of responses were lower in patients with B-cell malignancies undergoing therapy. Neutralizing antibody responses to omicron variants were reduced relative to wild-type and other variants. Additional prevention and prophylactic measures are warranted for poor vaccine responders.
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spelling pubmed-94892432022-09-21 IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans Frankel, Arthur Capozzola, Tazio Andrabi, Raiees Ahn, Chul Burton, Dennis Clin Lymphoma Myeloma Leuk Indolent B-Cell Lymphoma Serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein are surrogate markers of immune response. We evaluated antibody levels pre and post third vaccine (booster) and compared responses among different cancer-bearing and normal veterans. Both total and neutralizing antibody levels increased in most subjects after the booster, but the frequency and magnitude of responses were lower in patients with B-cell malignancies undergoing therapy. Neutralizing antibody responses to omicron variants were reduced relative to wild-type and other variants. Additional prevention and prophylactic measures are warranted for poor vaccine responders. Elsevier Inc. 2022-10 2022-09-21 /pmc/articles/PMC9489243/ http://dx.doi.org/10.1016/S2152-2650(22)01548-8 Text en Copyright © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Indolent B-Cell Lymphoma
Frankel, Arthur
Capozzola, Tazio
Andrabi, Raiees
Ahn, Chul
Burton, Dennis
IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
title IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
title_full IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
title_fullStr IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
title_full_unstemmed IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
title_short IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
title_sort ibcl-054 the effects of an mrna covid-19 vaccine booster on immune responses in cancer-bearing veterans
topic Indolent B-Cell Lymphoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489243/
http://dx.doi.org/10.1016/S2152-2650(22)01548-8
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