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Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis
BACKGROUND Acute pancreatitis (AP) is a common cause of hospital admissions. Diagnosing AP in patients presenting to emergency departments remains a challenge for physicians. Thus, we aimed to evaluate the diagnostic accuracy of galectin-3 to find a new and effective method for detecting AP. METHODS...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Iranian Association of Gastroerterology and Hepatology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489453/ https://www.ncbi.nlm.nih.gov/pubmed/36606007 http://dx.doi.org/10.34172/mejdd.2021.246 |
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author | Porozan, Samaneh Alavinejad, Pezhman Mozafari, Javad Kazem Mousavi, Hosein Delirrooyfard, Ali |
author_facet | Porozan, Samaneh Alavinejad, Pezhman Mozafari, Javad Kazem Mousavi, Hosein Delirrooyfard, Ali |
author_sort | Porozan, Samaneh |
collection | PubMed |
description | BACKGROUND Acute pancreatitis (AP) is a common cause of hospital admissions. Diagnosing AP in patients presenting to emergency departments remains a challenge for physicians. Thus, we aimed to evaluate the diagnostic accuracy of galectin-3 to find a new and effective method for detecting AP. METHODS In this prospective cross-sectional study, 43 patients with a manifestation of AP were enrolled. The serum levels of galectin-3 were measured at admission and 48 hours later and compared between the groups of patients with and without AP. RESULTS Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases compared with non-AP individuals. The area under the curve (AUC) for galectin-3 was 73.1%, which revealed a good accuracy in predicting the AP diagnosis. CONCLUSION Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases, and their diagnostic value was acceptable in the detection of AP. |
format | Online Article Text |
id | pubmed-9489453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Iranian Association of Gastroerterology and Hepatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-94894532023-01-04 Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis Porozan, Samaneh Alavinejad, Pezhman Mozafari, Javad Kazem Mousavi, Hosein Delirrooyfard, Ali Middle East J Dig Dis Original Article BACKGROUND Acute pancreatitis (AP) is a common cause of hospital admissions. Diagnosing AP in patients presenting to emergency departments remains a challenge for physicians. Thus, we aimed to evaluate the diagnostic accuracy of galectin-3 to find a new and effective method for detecting AP. METHODS In this prospective cross-sectional study, 43 patients with a manifestation of AP were enrolled. The serum levels of galectin-3 were measured at admission and 48 hours later and compared between the groups of patients with and without AP. RESULTS Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases compared with non-AP individuals. The area under the curve (AUC) for galectin-3 was 73.1%, which revealed a good accuracy in predicting the AP diagnosis. CONCLUSION Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases, and their diagnostic value was acceptable in the detection of AP. Iranian Association of Gastroerterology and Hepatology 2021-10 2021-07-23 /pmc/articles/PMC9489453/ /pubmed/36606007 http://dx.doi.org/10.34172/mejdd.2021.246 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by-nc/4.0/ This work is published by Middle East Journal of Digestive Diseases as an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Original Article Porozan, Samaneh Alavinejad, Pezhman Mozafari, Javad Kazem Mousavi, Hosein Delirrooyfard, Ali Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis |
title | Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis |
title_full | Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis |
title_fullStr | Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis |
title_full_unstemmed | Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis |
title_short | Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis |
title_sort | serum level of galectin-3 in early detection of acute pancreatitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489453/ https://www.ncbi.nlm.nih.gov/pubmed/36606007 http://dx.doi.org/10.34172/mejdd.2021.246 |
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