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Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis

BACKGROUND Acute pancreatitis (AP) is a common cause of hospital admissions. Diagnosing AP in patients presenting to emergency departments remains a challenge for physicians. Thus, we aimed to evaluate the diagnostic accuracy of galectin-3 to find a new and effective method for detecting AP. METHODS...

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Autores principales: Porozan, Samaneh, Alavinejad, Pezhman, Mozafari, Javad, Kazem Mousavi, Hosein, Delirrooyfard, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489453/
https://www.ncbi.nlm.nih.gov/pubmed/36606007
http://dx.doi.org/10.34172/mejdd.2021.246
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author Porozan, Samaneh
Alavinejad, Pezhman
Mozafari, Javad
Kazem Mousavi, Hosein
Delirrooyfard, Ali
author_facet Porozan, Samaneh
Alavinejad, Pezhman
Mozafari, Javad
Kazem Mousavi, Hosein
Delirrooyfard, Ali
author_sort Porozan, Samaneh
collection PubMed
description BACKGROUND Acute pancreatitis (AP) is a common cause of hospital admissions. Diagnosing AP in patients presenting to emergency departments remains a challenge for physicians. Thus, we aimed to evaluate the diagnostic accuracy of galectin-3 to find a new and effective method for detecting AP. METHODS In this prospective cross-sectional study, 43 patients with a manifestation of AP were enrolled. The serum levels of galectin-3 were measured at admission and 48 hours later and compared between the groups of patients with and without AP. RESULTS Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases compared with non-AP individuals. The area under the curve (AUC) for galectin-3 was 73.1%, which revealed a good accuracy in predicting the AP diagnosis. CONCLUSION Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases, and their diagnostic value was acceptable in the detection of AP.
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spelling pubmed-94894532023-01-04 Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis Porozan, Samaneh Alavinejad, Pezhman Mozafari, Javad Kazem Mousavi, Hosein Delirrooyfard, Ali Middle East J Dig Dis Original Article BACKGROUND Acute pancreatitis (AP) is a common cause of hospital admissions. Diagnosing AP in patients presenting to emergency departments remains a challenge for physicians. Thus, we aimed to evaluate the diagnostic accuracy of galectin-3 to find a new and effective method for detecting AP. METHODS In this prospective cross-sectional study, 43 patients with a manifestation of AP were enrolled. The serum levels of galectin-3 were measured at admission and 48 hours later and compared between the groups of patients with and without AP. RESULTS Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases compared with non-AP individuals. The area under the curve (AUC) for galectin-3 was 73.1%, which revealed a good accuracy in predicting the AP diagnosis. CONCLUSION Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases, and their diagnostic value was acceptable in the detection of AP. Iranian Association of Gastroerterology and Hepatology 2021-10 2021-07-23 /pmc/articles/PMC9489453/ /pubmed/36606007 http://dx.doi.org/10.34172/mejdd.2021.246 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by-nc/4.0/ This work is published by Middle East Journal of Digestive Diseases as an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Porozan, Samaneh
Alavinejad, Pezhman
Mozafari, Javad
Kazem Mousavi, Hosein
Delirrooyfard, Ali
Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis
title Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis
title_full Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis
title_fullStr Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis
title_full_unstemmed Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis
title_short Serum Level of Galectin-3 in Early Detection of Acute Pancreatitis
title_sort serum level of galectin-3 in early detection of acute pancreatitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489453/
https://www.ncbi.nlm.nih.gov/pubmed/36606007
http://dx.doi.org/10.34172/mejdd.2021.246
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