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Ra-223 induces clustered DNA damage and inhibits cell survival in several prostate cancer cell lines
The bone-seeking radiopharmaceutical Xofigo (Radium-223 dichloride) has demonstrated both extended survival and palliative effects in treatment of bone metastases in prostate cancer. The alpha-particle emitter Ra-223, targets regions undergoing active bone remodeling and strongly binds to bone hydro...
Autores principales: | Abramenkovs, Andris, Hariri, Mehran, Spiegelberg, Diana, Nilsson, Sten, Stenerlöw, Bo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489499/ https://www.ncbi.nlm.nih.gov/pubmed/36126563 http://dx.doi.org/10.1016/j.tranon.2022.101543 |
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