Cargando…
The Value of the Biomarkers Neuron-Specific Enolase and S100 Calcium-Binding Protein for Prediction of Mortality in Children Resuscitated After Cardiac Arrest
The aim of the present study was to assess the ability of the biomarkers neuron-specific enolase (NSE) and S100 calcium-binding protein b (S100b) to predict 30 day mortality in children resuscitated from cardiac arrest (CA). It was a prospective observational study at a single tertiary heart centre....
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489552/ https://www.ncbi.nlm.nih.gov/pubmed/35429240 http://dx.doi.org/10.1007/s00246-022-02899-9 |
_version_ | 1784792907902877696 |
---|---|
author | Bangshøj, Johanne Liebetrau, Benedikte Wiberg, Sebastian Gjedsted, Jakob Kjærgaard, Jesper Hassager, Christian Wanscher, Michael |
author_facet | Bangshøj, Johanne Liebetrau, Benedikte Wiberg, Sebastian Gjedsted, Jakob Kjærgaard, Jesper Hassager, Christian Wanscher, Michael |
author_sort | Bangshøj, Johanne |
collection | PubMed |
description | The aim of the present study was to assess the ability of the biomarkers neuron-specific enolase (NSE) and S100 calcium-binding protein b (S100b) to predict 30 day mortality in children resuscitated from cardiac arrest (CA). It was a prospective observational study at a single tertiary heart centre. Consecutive children were admitted after resuscitated in-hospital and out-of-hospital CA. Levels of NSE and S100b were analyzed from 12 to 24 hours, from 24 to 48 hours, and from 48 to 72 hours after admission. The primary endpoint was 30-day mortality. Differences in biomarker levels between survivors and non-survivors were analyzed with the Mann-Whitney U test. Receiver operating characteristics (ROC) curves were applied to assess the predictive ability of the biomarkers and the areas under the ROC curves (AUC) were presented. A total of 32 resuscitated CA patients were included, and 12 (38%) patients died within 30 days after resuscitation. We observed significantly higher levels of NSE and S100b in non-survivors compared to survivors at all timepoints from 12 to 72 hours after CA. NSE achieved AUCs from 0.91–0.98 for prediction of 30 day mortality, whereas S100b achieved AUCs from 0.93–0.94. An NSE cut-off of 61 μg/L sampled between 12–24 hours from admission achieved a sensitivity of 80% and a specificity of 100% for prediction of 30 day mortality. In children resuscitated from CA, the biomarkers NSE and S100b appear to be solid predictors of mortality after 30 days. |
format | Online Article Text |
id | pubmed-9489552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-94895522022-09-22 The Value of the Biomarkers Neuron-Specific Enolase and S100 Calcium-Binding Protein for Prediction of Mortality in Children Resuscitated After Cardiac Arrest Bangshøj, Johanne Liebetrau, Benedikte Wiberg, Sebastian Gjedsted, Jakob Kjærgaard, Jesper Hassager, Christian Wanscher, Michael Pediatr Cardiol Original Article The aim of the present study was to assess the ability of the biomarkers neuron-specific enolase (NSE) and S100 calcium-binding protein b (S100b) to predict 30 day mortality in children resuscitated from cardiac arrest (CA). It was a prospective observational study at a single tertiary heart centre. Consecutive children were admitted after resuscitated in-hospital and out-of-hospital CA. Levels of NSE and S100b were analyzed from 12 to 24 hours, from 24 to 48 hours, and from 48 to 72 hours after admission. The primary endpoint was 30-day mortality. Differences in biomarker levels between survivors and non-survivors were analyzed with the Mann-Whitney U test. Receiver operating characteristics (ROC) curves were applied to assess the predictive ability of the biomarkers and the areas under the ROC curves (AUC) were presented. A total of 32 resuscitated CA patients were included, and 12 (38%) patients died within 30 days after resuscitation. We observed significantly higher levels of NSE and S100b in non-survivors compared to survivors at all timepoints from 12 to 72 hours after CA. NSE achieved AUCs from 0.91–0.98 for prediction of 30 day mortality, whereas S100b achieved AUCs from 0.93–0.94. An NSE cut-off of 61 μg/L sampled between 12–24 hours from admission achieved a sensitivity of 80% and a specificity of 100% for prediction of 30 day mortality. In children resuscitated from CA, the biomarkers NSE and S100b appear to be solid predictors of mortality after 30 days. Springer US 2022-04-16 2022 /pmc/articles/PMC9489552/ /pubmed/35429240 http://dx.doi.org/10.1007/s00246-022-02899-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Bangshøj, Johanne Liebetrau, Benedikte Wiberg, Sebastian Gjedsted, Jakob Kjærgaard, Jesper Hassager, Christian Wanscher, Michael The Value of the Biomarkers Neuron-Specific Enolase and S100 Calcium-Binding Protein for Prediction of Mortality in Children Resuscitated After Cardiac Arrest |
title | The Value of the Biomarkers Neuron-Specific Enolase and S100 Calcium-Binding Protein for Prediction of Mortality in Children Resuscitated After Cardiac Arrest |
title_full | The Value of the Biomarkers Neuron-Specific Enolase and S100 Calcium-Binding Protein for Prediction of Mortality in Children Resuscitated After Cardiac Arrest |
title_fullStr | The Value of the Biomarkers Neuron-Specific Enolase and S100 Calcium-Binding Protein for Prediction of Mortality in Children Resuscitated After Cardiac Arrest |
title_full_unstemmed | The Value of the Biomarkers Neuron-Specific Enolase and S100 Calcium-Binding Protein for Prediction of Mortality in Children Resuscitated After Cardiac Arrest |
title_short | The Value of the Biomarkers Neuron-Specific Enolase and S100 Calcium-Binding Protein for Prediction of Mortality in Children Resuscitated After Cardiac Arrest |
title_sort | value of the biomarkers neuron-specific enolase and s100 calcium-binding protein for prediction of mortality in children resuscitated after cardiac arrest |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489552/ https://www.ncbi.nlm.nih.gov/pubmed/35429240 http://dx.doi.org/10.1007/s00246-022-02899-9 |
work_keys_str_mv | AT bangshøjjohanne thevalueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT liebetraubenedikte thevalueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT wibergsebastian thevalueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT gjedstedjakob thevalueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT kjærgaardjesper thevalueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT hassagerchristian thevalueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT wanschermichael thevalueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT bangshøjjohanne valueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT liebetraubenedikte valueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT wibergsebastian valueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT gjedstedjakob valueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT kjærgaardjesper valueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT hassagerchristian valueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest AT wanschermichael valueofthebiomarkersneuronspecificenolaseands100calciumbindingproteinforpredictionofmortalityinchildrenresuscitatedaftercardiacarrest |