An in silico–in vitro pipeline for drug cardiotoxicity screening identifies ionic pro‐arrhythmia mechanisms

BACKGROUND AND PURPOSE: Before advancing to clinical trials, new drugs are screened for their pro‐arrhythmic potential using a method that is overly conservative and provides limited mechanistic insight. The shortcomings of this approach can lead to the mis‐classification of beneficial drugs as pro‐...

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Detalles Bibliográficos
Autores principales: Clark, Alexander P., Wei, Siyu, Kalola, Darshan, Krogh‐Madsen, Trine, Christini, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489646/
https://www.ncbi.nlm.nih.gov/pubmed/35781252
http://dx.doi.org/10.1111/bph.15915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489646/
https://www.ncbi.nlm.nih.gov/pubmed/35781252
http://dx.doi.org/10.1111/bph.15915

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