Cargando…

An in silico–in vitro pipeline for drug cardiotoxicity screening identifies ionic pro‐arrhythmia mechanisms

BACKGROUND AND PURPOSE: Before advancing to clinical trials, new drugs are screened for their pro‐arrhythmic potential using a method that is overly conservative and provides limited mechanistic insight. The shortcomings of this approach can lead to the mis‐classification of beneficial drugs as pro‐...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clark, Alexander P., Wei, Siyu, Kalola, Darshan, Krogh‐Madsen, Trine, Christini, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489646/ https://www.ncbi.nlm.nih.gov/pubmed/35781252 http://dx.doi.org/10.1111/bph.15915

Ejemplares similares

Rapid ionic current phenotyping (RICP) identifies mechanistic underpinnings of iPSC-CM AP heterogeneity
por: Clark, Alexander P., et al.
Publicado: (2023)

Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing
por: Ortega, Francis A., et al.
Publicado: (2018)

Effects of Electrical and Structural Remodeling on Atrial Fibrillation Maintenance: A Simulation Study
por: Krogh-Madsen, Trine, et al.
Publicado: (2012)

Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis
por: Brown, Tashalee R., et al.
Publicado: (2015)

An in silico and in vitro pipeline for the rapid screening of helicase modulators
por: Papakonstantinou, Eleni, et al.
Publicado: (2020)

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings
por: Clark, Alexander P, et al.
Publicado: (2023)

Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes
por: Krogh-Madsen, Trine, et al.
Publicado: (2017)

Rapid Genetic Algorithm Optimization of a Mouse Computational Model: Benefits for Anthropomorphization of Neonatal Mouse Cardiomyocytes
por: Bot, Corina T., et al.
Publicado: (2012)

Non-Linear Dynamics of Cardiac Alternans: Subcellular to Tissue-Level Mechanisms of Arrhythmia
por: Gaeta, Stephen A., et al.
Publicado: (2012)

Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline
por: DeMarco, Kevin R., et al.
Publicado: (2021)

Cell-Specific Cardiac Electrophysiology Models
por: Groenendaal, Willemijn, et al.
Publicado: (2015)

In silico mechanisms of arsenic trioxide-induced cardiotoxicity
por: Li, Yacong, et al.
Publicado: (2022)

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity
por: Passini, Elisa, et al.
Publicado: (2017)

NHE Isoform Switching and KChIP2 Upregulation in Aging Porcine Atria
por: Kant, Ritu, et al.
Publicado: (2013)

In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment
por: Margara, Francesca, et al.
Publicado: (2021)

Tyrosine kinase inhibitors, ionic currents, and cardiac arrhythmia
por: Hu, Chi-Hao, et al.
Publicado: (2023)

Calibration of ionic and cellular cardiac electrophysiology models
por: Whittaker, Dominic G., et al.
Publicado: (2020)

Highlight report: Cardiotoxicity screening
por: Sachinidis, Agapios
Publicado: (2016)

The chemopreventive potential of lycopene against atrazine-induced cardiotoxicity: modulation of ionic homeostasis
por: Lin, Jia, et al.
Publicado: (2016)

Heritable arrhythmia syndromes associated with abnormal cardiac sodium channel function: ionic and non-ionic mechanisms
por: Rivaud, Mathilde R, et al.
Publicado: (2020)

A multilevel screening pipeline in zebrafish identifies therapeutic drugs for GAN
por: Lescouzères, Léa, et al.
Publicado: (2023)

In-silico study for the screening and preparation of ionic liquid-AVDs conjugate to combat COVID-19 surge
por: Saraswat, Juhi, et al.
Publicado: (2022)

The United States Food and Drug Administration and Prescription Drug Promotion
por: Kalola, Ankur S., et al.
Publicado: (2019)

A human population-based organotypic in vitro model for cardiotoxicity screening
por: Grimm, Fabian A., et al.
Publicado: (2018)

In silico analysis of the contribution of cardiomyocyte-fibroblast electromechanical interaction to the arrhythmia
por: Kursanov, Alexander, et al.
Publicado: (2023)

In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma
por: Pessetto, Ziyan Y., et al.
Publicado: (2016)

In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity
por: Adeyemi, Oluyomi Stephen, et al.
Publicado: (2019)

Combination of In Silico and In Vitro Screening to Identify Novel Glutamate Carboxypeptidase II Inhibitors
por: Temml, Veronika, et al.
Publicado: (2023)

A training pipeline of an arrhythmia classifier for atrial fibrillation detection using Photoplethysmography signal
por: Kudo, Sota, et al.
Publicado: (2023)

An In-Silico, In-Vitro and In-Vivo Combined Approach to Identify NMNATs as Potential Protein Targets of ProEGCG for Treatment of Endometriosis
por: Hung, Sze Wan, et al.
Publicado: (2021)

hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen
por: da Rocha, André Monteiro, et al.
Publicado: (2017)

Paradoxical Pro-angiogenic Effect of Low-Dose Ellipticine Identified by In Silico Drug Repurposing
por: Oh, Jisu, et al.
Publicado: (2021)

The Adverse Cardiovascular Effects and Cardiotoxicity of Kratom (Mitragyna speciosa Korth.): A Comprehensive Review
por: Leong Bin Abdullah, Mohammad Farris Iman, et al.
Publicado: (2021)

An In-silico Screening Strategy to the Prediction of New Inhibitors of COVID-19 M(pro) Protein
por: Abbasi, Maryam, et al.
Publicado: (2021)

Novel Natural Inhibitors of CYP1A2 Identified by in Silico and in Vitro Screening
por: Zhu, Ruixin, et al.
Publicado: (2011)

IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening
por: Tidten-Luksch, Naomi, et al.
Publicado: (2012)

In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans
por: Shi, Miaoying, et al.
Publicado: (2022)

The virtual heart as a platform for screening drug cardiotoxicity
por: Yuan, Yongfeng, et al.
Publicado: (2015)

Advances in Screening for Radiation-Associated Cardiotoxicity in Cancer Patients
por: Schiffer, Walter, et al.
Publicado: (2023)

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 M(pro) inhibitor
por: Zaidman, Daniel, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f5bp98c7o66anopksrenpm7nm2