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An in silico–in vitro pipeline for drug cardiotoxicity screening identifies ionic pro‐arrhythmia mechanisms
BACKGROUND AND PURPOSE: Before advancing to clinical trials, new drugs are screened for their pro‐arrhythmic potential using a method that is overly conservative and provides limited mechanistic insight. The shortcomings of this approach can lead to the mis‐classification of beneficial drugs as pro‐...
Autores principales: | Clark, Alexander P., Wei, Siyu, Kalola, Darshan, Krogh‐Madsen, Trine, Christini, David J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489646/ https://www.ncbi.nlm.nih.gov/pubmed/35781252 http://dx.doi.org/10.1111/bph.15915 |
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