Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice

Rhabdomyosarcoma, the most common pediatric sarcoma, has no effective treatment for the pleomorphic subtype. Still, what triggers transformation into this aggressive phenotype remains poorly understood. Here we used Ptch1(+/−)/ETV7(TG/+/−) mice with enhanced incidence of rhabdomyosarcoma to generate...

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Detalles Bibliográficos
Autores principales: Machado, Eda R., van de Vlekkert, Diantha, Sheppard, Heather S., Perry, Scott, Downing, Susanna M., Laxton, Jonathan, Ashmun, Richard, Finkelstein, David B., Neale, Geoffrey A., Hu, Huimin, Harwood, Frank C., Koo, Selene C., Grosveld, Gerard C., d’Azzo, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489700/
https://www.ncbi.nlm.nih.gov/pubmed/36127469
http://dx.doi.org/10.1038/s42003-022-03968-8

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