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Current understanding of osteoarthritis pathogenesis and relevant new approaches

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA...

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Autores principales: Tong, Liping, Yu, Huan, Huang, Xingyun, Shen, Jie, Xiao, Guozhi, Chen, Lin, Wang, Huaiyu, Xing, Lianping, Chen, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489702/
https://www.ncbi.nlm.nih.gov/pubmed/36127328
http://dx.doi.org/10.1038/s41413-022-00226-9
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author Tong, Liping
Yu, Huan
Huang, Xingyun
Shen, Jie
Xiao, Guozhi
Chen, Lin
Wang, Huaiyu
Xing, Lianping
Chen, Di
author_facet Tong, Liping
Yu, Huan
Huang, Xingyun
Shen, Jie
Xiao, Guozhi
Chen, Lin
Wang, Huaiyu
Xing, Lianping
Chen, Di
author_sort Tong, Liping
collection PubMed
description Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA development. To better understand the pathological mechanisms of OA, new approaches, methods, and techniques need to be used to understand OA pathogenesis. In this review, we first focus on the epigenetic regulation of OA, with a particular focus on DNA methylation, histone modification, and microRNA regulation, followed by a summary of several key mediators in OA-associated pain. We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain, such as CRISPR, scRNA sequencing, and lineage tracing. Next, we discuss the timely updates concerning cell death regulation in OA pathology, including pyroptosis, ferroptosis, and autophagy, as well as their individual roles in OA and potential molecular targets in treating OA. Finally, our review highlights new directions on the role of the synovial lymphatic system in OA. An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA.
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spelling pubmed-94897022022-09-22 Current understanding of osteoarthritis pathogenesis and relevant new approaches Tong, Liping Yu, Huan Huang, Xingyun Shen, Jie Xiao, Guozhi Chen, Lin Wang, Huaiyu Xing, Lianping Chen, Di Bone Res Review Article Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA development. To better understand the pathological mechanisms of OA, new approaches, methods, and techniques need to be used to understand OA pathogenesis. In this review, we first focus on the epigenetic regulation of OA, with a particular focus on DNA methylation, histone modification, and microRNA regulation, followed by a summary of several key mediators in OA-associated pain. We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain, such as CRISPR, scRNA sequencing, and lineage tracing. Next, we discuss the timely updates concerning cell death regulation in OA pathology, including pyroptosis, ferroptosis, and autophagy, as well as their individual roles in OA and potential molecular targets in treating OA. Finally, our review highlights new directions on the role of the synovial lymphatic system in OA. An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA. Nature Publishing Group UK 2022-09-20 /pmc/articles/PMC9489702/ /pubmed/36127328 http://dx.doi.org/10.1038/s41413-022-00226-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Tong, Liping
Yu, Huan
Huang, Xingyun
Shen, Jie
Xiao, Guozhi
Chen, Lin
Wang, Huaiyu
Xing, Lianping
Chen, Di
Current understanding of osteoarthritis pathogenesis and relevant new approaches
title Current understanding of osteoarthritis pathogenesis and relevant new approaches
title_full Current understanding of osteoarthritis pathogenesis and relevant new approaches
title_fullStr Current understanding of osteoarthritis pathogenesis and relevant new approaches
title_full_unstemmed Current understanding of osteoarthritis pathogenesis and relevant new approaches
title_short Current understanding of osteoarthritis pathogenesis and relevant new approaches
title_sort current understanding of osteoarthritis pathogenesis and relevant new approaches
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489702/
https://www.ncbi.nlm.nih.gov/pubmed/36127328
http://dx.doi.org/10.1038/s41413-022-00226-9
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