Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast

Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) from 9 BC patients and compare them to published EC taxonomies from lung tumors. Angiogenic ECs are phenotypically simil...

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Detalles Bibliográficos
Autores principales: Geldhof, Vincent, de Rooij, Laura P. M. H., Sokol, Liliana, Amersfoort, Jacob, De Schepper, Maxim, Rohlenova, Katerina, Hoste, Griet, Vanderstichele, Adriaan, Delsupehe, Anne-Marie, Isnaldi, Edoardo, Dai, Naima, Taverna, Federico, Khan, Shawez, Truong, Anh-Co K., Teuwen, Laure-Anne, Richard, François, Treps, Lucas, Smeets, Ann, Nevelsteen, Ines, Weynand, Birgit, Vinckier, Stefan, Schoonjans, Luc, Kalucka, Joanna, Desmedt, Christine, Neven, Patrick, Mazzone, Massimiliano, Floris, Giuseppe, Punie, Kevin, Dewerchin, Mieke, Eelen, Guy, Wildiers, Hans, Li, Xuri, Luo, Yonglun, Carmeliet, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489707/
https://www.ncbi.nlm.nih.gov/pubmed/36127427
http://dx.doi.org/10.1038/s41467-022-33052-y

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